Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/55910
Share/Impact:
Title: Synthesis, Structure and Bactericide Activity of (Aminophosphane)gold(I) Thiolate Complexes
Authors: Fillat, María F., Gimeno, M. Concepción, Laguna, Antonio, Latorre, Encarnación, Ortego, Lourdes, Villacampa, M. Dolores
Keywords: Gold
Biological activity
P li­gands
Thiols
X-ray diffraction
Issue Date: Mar-2011
Publisher: Wiley-VCH
Abstract: Reaction of the aminophosphane ligands 2-(diphenylphosphanylamino)pyridine (Ph2PNHpy, 1) and 3-(diphenylphosphanylamino)-1,2,4-triazole [Ph2PNH(Htrz), 2] with the gold(I) compound [AuCl(tht)] (tht = tetrahydrothiophene) gave the complexes [AuCl(Ph2PNHpy)] (3) and [AuCl{Ph2PNH(Htrz)}] (4), respectively. A series of new gold(I) thiolate derivatives were synthesized from the reactions of complex 3 or 4 with 1 equiv. of a deprotonated thiol ligand. Complexes [Au(SR)(PPh2NHpy)] (5–8) were prepared by reaction of complex 3 with the corresponding thiol HSR [HSR = 2-mercaptopyridine (2-HSpy), 2-mercaptonicotinic acid (2-H2-mna), 2-thiouracil (2-HTU) or 2-thiocytosine (2-HTC)] in the presence of sodium carbonate or triethylamine. Complexes [Au(SR){PPh2NH(Htrz)}] (9–11) were prepared by the treatment of complex 4 with triethylamine and the respective thiol HSR [HSR = 2-mercaptopyridine (2-HSpy), 2-thiocytosine (2-HTC) or 6-thioguanine (6-HTG)]. The susceptibility of Enterococcus faecalis ATCC25923, Staphylococcus aureus ATCC29213 and Escherichia coli TG1 towards the synthesized gold(I) complexes was evaluated. Some of them exhibit powerful anti-bacterial activity, being more efficient against Gram-positive microorganisms. Complexes 7–9 and 11 present excellent activity against E. faecalis, whereas the highest sensitivity of S. aureus was against complexes 7 and 8. The structures of complexes 4, 5, 8 and 9 were determined by X-ray structural analysis. None of the four compounds shows aurophilic interactions between the gold(I) centres in the crystals. The four complexes possess intermolecular hydrogen bonds that lead to supramolecular arrangements.
Description: 9 páginas, 8 figuras, 4 tablas, 4 esuqemas.
Publisher version (URL): http://dx.doi.org/10.1002/ejic.201001195
URI: http://hdl.handle.net/10261/55910
ISSN: 1434-1948
???metadata.dc.identifier.doi???: 10.1002/ejic.201001195
Citation: European Journal of Inorganic Chemistry 9: 1487-1495 (2011)
Appears in Collections:(ICMA) Artículos
Files in This Item:
File Description SizeFormat 
restringido.pdf21,67 kBAdobe PDFView/Open
Show full item record
 
CSIC SFX LinksSFX Query


Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.