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Triacylglycerol-rich lipoproteins trigger the phosphorylation of extracellular-signal regulated kinases in vascular cells

AuthorsPacheco, Yolanda M. ; Abia, Rocío ; Perona, Javier S. ; Meier, Kathryn E.; Montero, Emilio; Ruiz-Gutiérrez, Valentina ; Muriana, Francisco J. G.
KeywordsTriacylglycerol-rich lipoproteins
Vascular cells
Mitogen-activated protein kinase
Issue Date9-Aug-2002
CitationLife Sciences 71(12): 1351-1360 (2002)
AbstractPostprandial triacylglycerol-rich lipoproteins (TRL) have been implicated in the pathophysiology of atherosclerosis, but the intracellular processes by which TRL could affect vascular function are still unknown. Incubation of TRL obtained at 2 h postprandial period with vascular smooth muscle cells (VSMC) produced a tyrosine phosphorylation of the extracellular signal-regulated kinases 1 and 2 (ERK1 and ERK2) that belong to the mitogen-activated protein kinase (MAPK) family. The activation of ERK1 and ERK2 had a maximum at 15 min, returned to baseline by 60 min, and was partially depleted after incubation of cells with a MAPKK inhibitor (PD 098059). In addition, postprandial TRL did competent VSMC for DNA replication through a MAPK pathway. These effects were dependent of the lipid composition of TRL. Our observations suggest that postprandial TRL can trigger activation of the MAPK pathway and induce a mitogenic response in VSMC in a lipid-dependent fashion.
Publisher version (URL)http://dx.doi.org/10.1016/S0024-3205(02)01860-X
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