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Título: | The human CD6 gene is transcriptionally regulated by RUNX and Ets transcription factors in T cells |
Autor: | Arman, M.; Aguilera-Montilla, Noemí CSIC ORCID; Mas, V.; Puig-Kröger, Amaya CSIC ORCID; Pignatelli, M.; Guigó, Roderic ; Corbí, Angel L. ; Lozano, Francisco | Palabras clave: | Human CD6 T cells Gene regulation Transcription factors RUNX Ets |
Fecha de publicación: | jul-2009 | Editor: | Elsevier | Citación: | Molecular Immunology, 46 (11-12) : 2226-2235 | Resumen: | CD6 is a lymphocyte surface receptor involved in lymphocyte activation and differentiation processes that is constitutively expressed on developing and mature T cells and on the B1a cells. To define the molecular basis for the tissue-specific expression of CD6 we have identified the transcription factors that control the activity of the proximal regulatory region of the human CD6 gene. The TATA-less CD6 promoter contains multiple transcriptional start sites, and its preferential activity in human T lymphocytes is dependent on RUNX- and Ets-binding sites located within a highly conserved region. RUNX and Ets-1 factors transactivated the CD6 promoter through recognition of the −215 and −230 binding sites, respectively. Chromatin immunoprecipitation assays revealed that RUNX1 constitutively occupies the CD6 promoter in vivo, and knockdown experiments demonstrated that the steady-state level of CD6 mRNA is dependent on the expression of RUNX1, RUNX3 and Ets-1 transcription factors. Therefore, RUNX1/3 and Ets1 control the expression of CD6 in human T lymphocytes, thus expanding the range of T-cell specific and developmentally regulated lymphocyte gene targets involved in T-cell activation and differentiation | Descripción: | 10 páginas, 6 figuras -- PAGS nros. 2226-2235 | Versión del editor: | http://dx.doi.org/10.1016/j.molimm.2009.04.018 | URI: | http://hdl.handle.net/10261/55810 | DOI: | 10.1016/j.molimm.2009.04.018 | ISSN: | 0161-5890 |
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