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dc.contributor.authorPrades, Jesús-
dc.contributor.authorAlemany, Regina-
dc.contributor.authorPerona, Javier S.-
dc.contributor.authorFunari, Sergio S.-
dc.contributor.authorVögler, Oliver-
dc.contributor.authorRuiz-Gutiérrez, Valentina-
dc.contributor.authorEscribá, Pablo V.-
dc.contributor.authorBarceló, Francisca-
dc.identifier.citationMolecular Membrane Biology 25(1): 46-57 (2012)es_ES
dc.identifier.otherPMID: 17852735-
dc.description.abstractGenetic hypertension is associated with alterations in lipid metabolism, membrane lipid composition and membrane-protein function. 2-Hydroxyoleic acid (2OHOA) is a new antihypertensive molecule that regulates the structure of model membranes and their interaction with certain peripheral signalling proteins in vitro. While the effect of 2OHOA on elevated blood pressure is thought to arise through its influence on signalling proteins, its effects on membrane lipid composition remain to be assessed. 2OHOA administration altered the lipid membrane composition of hypertensive and normotensive rat plasma membranes, and increased the fluidity of reconstituted liver membranes from hypertensive rats. In spontaneously hypertensive rats (SHR), treatment with 2OHOA increased the cholesterol and sphingomyelin content while decreasing that of phosphatidylserine-phosphatidylinositol lipids. In addition, monounsaturated fatty acid levels increased as well as the propensity of reconstituted membranes to form HII-phases. These data suggest that 2OHOA regulates lipid metabolism that is altered in hypertensive animals, and that it affects the structural properties of liver plasma membranes in SHR. These changes in the structural properties of the plasma membrane may modulate the activity of signalling proteins that associate with the cell membrane such as the Gαq/11 protein and hence, signal transduction.es_ES
dc.publisherInforma Healthcarees_ES
dc.subjectHypertensive ratses_ES
dc.subjectNormotensive ratses_ES
dc.subjectLiver plasma membranees_ES
dc.subjectMembrane structurees_ES
dc.subjectMembrane fluidityes_ES
dc.titleEffects of 2-hydroxyoleic acid on the structural properties of biological and model plasma membraneses_ES
dc.description.peerreviewedPeer reviewedes_ES
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