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Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Winderink, Yvette S. | - |
dc.contributor.author | Martínez-Rodríguez, Gonzalo | - |
dc.contributor.author | Yúfera, Manuel | - |
dc.contributor.author | Martín Montero, Ignacio | - |
dc.contributor.author | Flik, Gert | - |
dc.contributor.author | Mancera, Juan Miguel | - |
dc.contributor.author | Klaren, Peter H. M. | - |
dc.date.accessioned | 2012-09-03T10:27:22Z | - |
dc.date.available | 2012-09-03T10:27:22Z | - |
dc.date.issued | 2012-08 | - |
dc.identifier.citation | Comparative Biochemistry and Physiology - A - Molecular and Integrative Physiology 162(4): 317-322 (2012) | es_ES |
dc.identifier.issn | 1095-6433 | - |
dc.identifier.other | PMID: 22516685 | - |
dc.identifier.uri | http://hdl.handle.net/10261/55454 | - |
dc.description.abstract | In vertebrates, stress and thyroid systems interact closely, most likely because of the involvement of both systems in energy metabolism. However, studies on these interactions, especially during larval development, are scarce. Recently, cDNAs coding for corticotropin-releasing hormone (CRH) and CRH-binding protein (CRH-BP), two key players in the regulation of the neuroendocrine stress response, were characterized for the flatfish Senegalese sole (. Solea senegalensis). To investigate the involvement of stress and thyroid systems in this species, the effects of food deprivation during early development of . S. senegalensis were assessed. Growth was arrested in food-deprived post-larvae, which was also reflected by decreased carbon and nitrogen contents, indicating increased catabolism. Food deprivation induces chronic stress, as illustrated by enhanced whole-body cortisol levels, as well as an up regulation of . crh and a decrease of . crh-bp expression levels. Furthermore, whole-body total T3 concentrations of food-deprived post-larvae were reduced, although . tshβ subunit expression levels remained unaffected. Our results show that food deprivation is a chronic stressor that induces energy-releasing catabolic processes that compensate for the reduced energy intake, and inhibits anabolic processes via the peripheral thyroid system. | es_ES |
dc.description.sponsorship | This work was partially funded by grants AGL2007-61211/ACU (Ministerio Educación y Ciencia of Spain) and Proyecto de Excelencia PO7-RNM-02843 (Consejería de Innovación, Ciencia y Empresa, Junta de Andalucía, Spain) to J.M.M., as well as by the project AQUAGENOMICS (CSD2007-00002, Consolider-Ingenio 2010 Program, MICINN, Spain) to M.Y. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.rights | openAccess | es_ES |
dc.subject | Cortisol | es_ES |
dc.subject | CRH | es_ES |
dc.subject | CRH-BP | es_ES |
dc.subject | Food deprivation | es_ES |
dc.subject | Thyroid hormones | es_ES |
dc.subject | TSH | es_ES |
dc.subject | Solea senegalensis | es_ES |
dc.title | Food deprivation induces chronic stress and affects thyroid hormone metabolism in Senegalese sole (Solea senegalensis) post-larvae | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1016/j.cbpa.2012.03.023 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.1016/j.cbpa.2012.03.023 | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
item.languageiso639-1 | en | - |
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Wunderink_et_al_2012_Postprint.pdf | 351,81 kB | Adobe PDF | Visualizar/Abrir |
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