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Closed Access item Incorporation of 2nd and 3rd Generation Bisphosphonates on Hydroxyfluorapatite

Authors:Rodríguez-Lorenzo, Luis M.
Vázquez Lasa, Blanca
San Román, Julio
Gross, K. A.
Keywords:bisphosphonates, hydroxyfluorapatite, surface modification
Issue Date:2006
Publisher:Trans Tech Publications
Citation:Key Engineering Materials 309-311: 899-902 (2006)
Abstract:Bisphosphonates (BPs) may play an important role in minimizing osteolysis. In this work two new bisphosphonates pertaining to second and third generations respectively, have been synthesized and incorporated onto a chemically enriched hydroxyapatite. BP synthesis has been performed by adding H3PO3, PCl3 and methanesulfonic acid over 4-aminophenyl acetic acid (APBP) and 1-H-indole-3-acetic acid (IBP) respectively at 65ºC in a N2 atmosphere. These compounds bear a primary amine group bonded to an aromatic ring, and a secondary amine group within a heterocyclic ring respectively. A chemically enriched hydroxyapatite with a chemical content corresponding to a 50% fluorided hydroxyapatite has been synthesized. Ceramic bodies manufactured by uniaxial pressure followed by cold isostatic press have a 97% density and submicron grain size. The BP was adsorbed onto the surface by immersion in a stirred solution at 37ºC for 48 hours. A 10-fold decrease of the surface energy was observed for bodies modified with the APBP whereas only a 25 % decrease is obtained for bodies loaded with the bisphosphonate loaded with the IBP
Publisher version (URL):http://dx.doi.org/10.4028/www.scientific.net/KEM.309-311.899
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