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Title

Acrylic Injectable and Self-Curing Formulations for the Local Release of Bisphosphonates in Bone Tissue

AuthorsRodríguez-Lorenzo, Luis M. ; Fernández, Mar; Parra, J.; Vázquez Lasa, Blanca
Keywordsbone cement
acrylic
osteoporosis
controlled release
bone remodeling
Issue Date2007
PublisherWiley-Blackwell
CitationJournal of Biomedical Materials Research Part B: Applied Biomaterials 83B : 596–608 (2007)
AbstractTwo bisphosphonates (BPs), namely 1-hydroxy-2-[4-aminophenyl]ethane-1,1-diphosphonic acid (APBP) and 1-hydroxy-2-[3-indolyl]ethane-1,1-diphosphonic acid (IBP), have been synthesized and incorporated to acrylic injectable and self-curing formulations. Alendronic acid monosodium trihydrated salt (ALN) containing cement was formulated as control. These systems have potential applications in low density hard tissues affected by ailments characterized by a high osteoclastic resorption, i.e. osteoporosis and osteolysis. Values of curing parameters of APBP and IBP were acceptable to obtain pastes with enough fluency to be injected through a biopsy needle into the bone cavity. Working times ranged between 8 and 15 min and maximum temperature was around 508C. Cured systems stored for a month in synthetic body fluid had compressive strengths between 90 and 96 MPa and modulus between 1.2 and 1.3 GPa, which suggest mechanical stabilization after setting and in the short time. BPs were released in PBS at an initial rate depending on the corresponding chemical structure in the order ALN > APBP > IBP to give final concentrations in PBS of 2.21, 0.44, and 0.19 mol/mL for ALN, APBP, and IBP, respectively. Cytotoxicities of bisphosphonates were evaluated, IC50 values being in the order APBP > ALN > IBP. Absence of cytotoxicity coming from leachables of the cured systems was observed in all cases independently of the BP. An improved cell growth and proliferation for the systems loaded with APBP and IBP compared with that loaded with ALN was observed, as assessed by measuring cell adhesion and proliferation, and total DNA content
Publisher version (URL)http://dx.doi.org/10.1002/jbm.b.30833
URIhttp://hdl.handle.net/10261/55135
DOI10.1002/jbm.b.30833
ISSN1552-4973
Appears in Collections:(ICTP) Artículos
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