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Title

Acrylic bone cements with bismuth salicylate: behavior in simulated physiological conditions

AuthorsHernández, Lidia; Vázquez Lasa, Blanca; López-Bravo, A. ; Parra, J.; Goñi, I.; Gurruchaga, M.
Keywordsbiocompatibility
bone cement
mechanical properties
spinal implant
toxicity
Issue Date2007
PublisherWiley-Blackwell
CitationJournal of Biomedical Materials Research Part A 80 : 321–332 (2007)
AbstractIn a previous work, we reported the development of acrylic bone cement formulations for application in percutaneous vertebroplasty, by using bismuth salicylate (BS) as the radiopaque agent. Our objective was to obtain high radiopacity along with a therapeutical effect produced by the release of salicylic acid in situ. To follow that study, the setting kinetics and static and dynamical mechanical properties of the BS cements were studied in simulated physiological conditions. Moreover, radiopacity after various times of immersion in saline and the wettability of the cements surfaces were determined. The study finished with the analysis of the biological response. From the results, it can be concluded that physiological conditions did not affect negatively to the cements performance, since all BS-loaded cements fulfilled the ISO standard requirements. Radiopacity of the formulations was maintained over time and cements with BS were found to be biocompatible
Publisher version (URL)http://dx.doi.org/10.1002/jbm.a.30947
URIhttp://hdl.handle.net/10261/55120
DOI10.1002/jbm.a.30947
ISSN1549-3296
Appears in Collections:(ICTP) Artículos
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