Digital.CSIC > Biología y Biomedicina > Instituto de Neurociencias (IN) > (IN) Artículos >




Closed Access item Reciprocal repression between Sox3 and Snail transcription factors defines embryonic territories at gastrulation

Authors:Acloque, Hervé
Ocaña, Oscar H.
Matheu, Ander
Rizzoti, Karine
Wise, Clare
Lovell-Badge, Robin
Nieto, M. Ángela
Issue Date:Sep-2011
Citation:Developmental Cell 21(3): 546-558 (2011)
Abstract:In developing amniote embryos, the first epithelial-to-mesenchymal transition (EMT) occurs at gastrulation, when a subset of epiblast cells moves to the primitive streak and undergoes EMT to internalize and generate the mesoderm and the endoderm. We show that in the chick embryo this decision to internalize is mediated by reciprocal transcriptional repression of Snail2 and Sox3 factors. We also show that the relationship between Sox3 and Snail is conserved in the mouse embryo and in human cancer cells. In the embryo, Snail-expressing cells ingress at the primitive streak, whereas Sox3-positive cells, which are unable to ingress, ensure the formation of ectodermal derivatives. Thus, the subdivision of the early embryo into the two main territories, ectodermal and mesendodermal, is regulated by changes in cell behavior mediated by the antagonistic relationship between Sox3 and Snail transcription factors.
Description:13 p., 8 figures and references.
Publisher version (URL):http://dx.doi.org/10.1016/j.devcel.2011.07.005
E-ISSNmetadata.dc.identifier.doi = DOI:1878-1551
Appears in Collections:(IN) Artículos

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.