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Título : Characterization of a C3 and a factor B-like in the carpet-shell clam, Ruditapes decussatus
Autor : Prado-Álvarez, María, Rotllant, Josep, Gestal, C., Novoa, Beatriz, Figueras, Antonio
Palabras clave : Clam
Ruditapes decussatus
Factor B
Gene expression
Fecha de publicación : 2009
Editor: Elsevier
Resumen: The alternative pathway is considered to be the most ancient route for activation of the complement system. Herein, we report the characterization of C3 and factor B-like proteins in the clam Ruditapes decussatus, termed Rd-C3 and Rd-Bf-like. The Rd-C3 is a three-chain protein, similar to other protoC3 proteins, and the Rd-Bf-like is composed of two complement control protein modules (CCP domains) that differ from other described Bf proteins. The inoculation of clams with live bacteria did not result in induction of these functions, but inhibited the expression of Rd-C3 and Rd-Bf-like.
Descripción : 11 páginas, 7 figuras, 2 tablas
Versión del editor:
ISSN: 1050-4648
DOI: 10.1016/j.fsi.2008.11.015
Citación : Fish and Shellfish Immunology 26(2): 305-315 (2009)
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