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Closed Access item Characterization of a C3 and a factor B-like in the carpet-shell clam, Ruditapes decussatus

Authors:Prado-Álvarez, María
Rotllant, Josep
Gestal, C.
Novoa, Beatriz
Figueras, Antonio
Keywords:Clam, Ruditapes decussatus, Complement, C3, Factor B, Gene expression
Issue Date:2009
Citation:Fish and Shellfish Immunology 26(2): 305-315 (2009)
Abstract:The alternative pathway is considered to be the most ancient route for activation of the complement system. Herein, we report the characterization of C3 and factor B-like proteins in the clam Ruditapes decussatus, termed Rd-C3 and Rd-Bf-like. The Rd-C3 is a three-chain protein, similar to other protoC3 proteins, and the Rd-Bf-like is composed of two complement control protein modules (CCP domains) that differ from other described Bf proteins. The inoculation of clams with live bacteria did not result in induction of these functions, but inhibited the expression of Rd-C3 and Rd-Bf-like.
Description:11 páginas, 7 figuras, 2 tablas
Publisher version (URL):http://dx.doi.org/10.1016/j.fsi.2008.11.015
Appears in Collections:(IIM) Artículos

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