Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/54930
Título : Duration of protective immunity and antibody responses in cattle immunised against alcelaphine herpesvirus-1-induced malignant catarrhal fever
Autor : Russell, George C., Benavides, Julio, Grant, Dawn, Todd, Helen, Deane, David, Percival, Ann, Thomson, Jackie, Connelly, Maira, Haig, David M.
Fecha de publicación : 11-Jun-2012
Editor: BioMed Central
Resumen: Abstract Protection of cattle from alcelaphine herpesvirus-1 (AlHV-1)-induced malignant catarrhal fever (MCF) has been described previously, using an attenuated virus vaccine in an unlicensed adjuvant. The vaccine was hypothesised to induce a protective barrier of virus-neutralising antibody in the oro-nasal region, supported by the observation of high titre neutralising antibodies in nasal secretions of protected animals. Here we describe further analysis of this vaccine strategy, studying the effectiveness of the vaccine formulated with a licensed adjuvant; the duration of immunity induced; and the virus-specific antibody responses in plasma and nasal secretions. The results presented here show that the attenuated AlHV-1 vaccine in a licensed adjuvant protected cattle from fatal intranasal challenge with pathogenic AlHV-1 at three or six months. In addition, animals protected from MCF had significantly higher initial anti-viral antibody titres than animals that succumbed to disease; and these antibody titres remained relatively stable after challenge, while titres in vaccinated animals with MCF increased significantly prior to the onset of clinical disease. These data support the view that a mucosal barrier of neutralising antibody blocks infection of vaccinated animals and suggests that the magnitude of the initial response may correlate with long-term protection. Interestingly, the high titre virus-neutralising antibody responses seen in animals that succumbed to MCF after vaccination were not protective.
URI : http://hdl.handle.net/10261/54930
Identificadores: http://dx.doi.org/10.1186/1297-9716-43-51
Citación : Veterinary Research 43(1) : 51- (2012)
Appears in Collections:(IGM) Artículos

Files in This Item:
File Description SizeFormat 
1297-9716-43-51.xml108,02 kBXMLView/Open
1297-9716-43-51-S1.DOC32 kBMicrosoft WordView/Open
1297-9716-43-51.pdf734,06 kBAdobe PDFView/Open
Show full item record
 
CSIC SFX LinksSFX Query

Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.