Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/54432
COMPARTIR / EXPORTAR:
logo share SHARE logo core CORE BASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE

Invitar a revisión por pares abierta
Título

Fish models in prion biology: Underwater issues

AutorMálaga-Trillo, Edward; Salta, Evgenia; Figueras Huerta, Antonio ; Panagiotidis, Cynthia; Sklaviadis, Theodoros
Palabras clavePrion protein
Transmissible spongiform encephalopathy
Neurodegeneration
Fish
Zebrafish
Fecha de publicación2011
EditorElsevier
CitaciónBiochimica et Biophysica Acta - Molecular Basis of Disease 1812(3): 402-414 (2011)
ResumenTransmissible spongiform encephalopathies (TSEs), otherwise known as prion disorders, are fatal diseases causing neurodegeneration in a wide range of mammalian hosts, including humans. The causative agents – prions – are thought to be composed of a rogue isoform of the endogenous prion protein (PrP). Beyond these and other basic concepts, fundamental questions in prion biology remain unanswered, such as the physiological function of PrP, the molecular mechanisms underlying prion pathogenesis, and the origin of prions. To date, the occurrence of TSEs in lower vertebrates like fish and birds has received only limited attention, despite the fact that these animals possess bona fide PrPs. Recent findings, however, have brought fish before the footlights of prion research. Fish models are beginning to provide useful insights into the roles of PrP in health and disease, as well as the potential risk of prion transmission between fish and mammals. Although still in its infancy, the use of fish models in TSE research could significantly improve our basic understanding of prion diseases, and also help anticipate risks to public health. This article is part of a Special Issue entitled Zebrafish Models of Neurological Diseases.
Descripción13 páginas, 5 figuras, 1 tabla
Versión del editorhttp://dx.doi.org/10.1016/j.bbadis.2010.09.013
URIhttp://hdl.handle.net/10261/54432
DOI10.1016/j.bbadis.2010.09.013
ISSN0925-4439
Aparece en las colecciones: (IIM) Artículos

Mostrar el registro completo

CORE Recommender

SCOPUSTM   
Citations

25
checked on 23-mar-2024

WEB OF SCIENCETM
Citations

19
checked on 26-feb-2024

Page view(s)

305
checked on 28-mar-2024

Google ScholarTM

Check

Altmetric

Altmetric


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.