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Title: Structural basis for the catalytic mechanism and substrate specificity of the ribonuclease α-sarcin
Authors: Campos Olivas, Ramón, Bruix, M., Santoro, Jorge, Martínez del Pozo, Alvaro, Lacadena, Javier, Gavilanes, José G., Rico, Manuel
Issue Date: 1996
Publisher: Elsevier
Abstract: -Sarcin is a ribosome-inactivating protein which selectively cleaves a single phosphodiester bond in a universally conserved sequence of the major rRNA. The solution structure of α-sarcin has been determined on the basis of 1898 distance and angular experimental constraints from NMR spectroscopy. It reveals a catalytic mechanism analogous to that of the T1 family of ribonucleases while its exquisite specificity resides in the contacts provided by its distinctive loops.
Identifiers: doi: 10.1016/S0014-5793(96)01320-8
issn: 0014-5793
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Citation: FEBS Letters 399(1-2): 163- 165 (1996)
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