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Título: | Structural basis for the catalytic mechanism and substrate specificity of the ribonuclease α-sarcin |
Autor: | Campos-Olivas, Ramón CSIC ORCID; Bruix, M. CSIC ORCID ; Santoro, Jorge CSIC; Martínez del Pozo, Álvaro; Lacadena, Javier; Gavilanes, José G.; Rico, Manuel CSIC | Fecha de publicación: | 1996 | Editor: | Elsevier | Citación: | FEBS Letters 399(1-2): 163- 165 (1996) | Resumen: | -Sarcin is a ribosome-inactivating protein which selectively cleaves a single phosphodiester bond in a universally conserved sequence of the major rRNA. The solution structure of α-sarcin has been determined on the basis of 1898 distance and angular experimental constraints from NMR spectroscopy. It reveals a catalytic mechanism analogous to that of the T1 family of ribonucleases while its exquisite specificity resides in the contacts provided by its distinctive loops. | URI: | http://hdl.handle.net/10261/54396 | DOI: | 10.1016/S0014-5793(96)01320-8 | Identificadores: | doi: 10.1016/S0014-5793(96)01320-8 issn: 0014-5793 |
Aparece en las colecciones: | (CFMAC-IEM) Artículos |
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