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Closed Access item Structural basis for the catalytic mechanism and substrate specificity of the ribonuclease α-sarcin

Authors:Campos Olivas, Ramón
Bruix, M.
Santoro, Jorge
Martínez del Pozo, Alvaro
Lacadena, Javier
Gavilanes, José G.
Rico, Manuel
Issue Date:1996
Citation:FEBS Letters 399(1-2): 163- 165 (1996)
Abstract:-Sarcin is a ribosome-inactivating protein which selectively cleaves a single phosphodiester bond in a universally conserved sequence of the major rRNA. The solution structure of α-sarcin has been determined on the basis of 1898 distance and angular experimental constraints from NMR spectroscopy. It reveals a catalytic mechanism analogous to that of the T1 family of ribonucleases while its exquisite specificity resides in the contacts provided by its distinctive loops.
Identifiers:doi: 10.1016/S0014-5793(96)01320-8
issn: 0014-5793
Appears in Collections:(CFMAC-IEM) Artículos

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