Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/53548
Title: The dendritic cell side of the immunological synapse: exploring terra incognita
Authors: Rodríguez-Fernández, José Luis, Riol-Blanco, Lorena, Delgado-Martín, Cristina, Escribano, Cristina
Keywords: cancer
cell
clinical
deliveri
diseas
drug
gene
have
prostat
therapeutic
therapi
transplantation
treatment
vaccination
Issue Date: 7-Oct-2009
Publisher: Discovey Medicine
Abstract: The activation and clonal expansion of naive T cells by antigen-loaded dendritic cells (DCs) in the lymph nodes is a key event during immune response. This activation involves the formation of a specialized cell-cell contact region, formed between a mature DC and a CD4 T cell, which is called immunological synapse (IS). The IS includes a DC and a T cell side that we call IS(DC) and IS(T cell), respectively. Most studies on the IS have focused on the IS(T cell) and the information gathered on the IS(DC) is sparse. However, lines of emerging evidence indicate that the IS(DC), likewise the IS(T cell), is a signaling and functional region that makes important contribution to T cell activation and immune response
Description: 5 páginas -- PAGS nros. 108-112
Publisher version (URL): http://www.discoverymedicine.com
URI: http://hdl.handle.net/10261/53548
ISSN: 1539-6509
Citation: Discovery Medicine 8(42):108-112(2009)
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