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Closed Access item The dendritic cell side of the immunological synapse: exploring terra incognita

Authors:Rodríguez-Fernández, José Luis
Riol-Blanco, Lorena
Delgado-Martín, Cristina
Escribano, Cristina
Keywords:cancer, cell, clinical, deliveri, diseas, drug, gene, have, prostat, therapeutic, therapi, transplantation, treatment, vaccination
Issue Date:7-Oct-2009
Publisher:Discovey Medicine
Citation:Discovery Medicine 8(42):108-112(2009)
Abstract:The activation and clonal expansion of naive T cells by antigen-loaded dendritic cells (DCs) in the lymph nodes is a key event during immune response. This activation involves the formation of a specialized cell-cell contact region, formed between a mature DC and a CD4 T cell, which is called immunological synapse (IS). The IS includes a DC and a T cell side that we call IS(DC) and IS(T cell), respectively. Most studies on the IS have focused on the IS(T cell) and the information gathered on the IS(DC) is sparse. However, lines of emerging evidence indicate that the IS(DC), likewise the IS(T cell), is a signaling and functional region that makes important contribution to T cell activation and immune response
Description:5 páginas -- PAGS nros. 108-112
Publisher version (URL):http://www.discoverymedicine.com
E-ISSNmetadata.dc.identifier.doi = DOI:1944-7930
Appears in Collections:(CIB) Artículos

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