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Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/53548
Title: The dendritic cell side of the immunological synapse: exploring terra incognita
Authors: Rodríguez-Fernández, José Luis; Riol-Blanco, Lorena; Delgado-Martín, Cristina; Escribano, Cristina
Keywords: Cancer
Cell
Clinical
Delivery
Disease
Drug
Gene
Prostate
Therapeutic
Therapy
Transplantation
Treatment
Vaccination
Issue Date: 7-Oct-2009
Publisher: Discovey Medicine
Citation: Discovery Medicine 8(42):108-112(2009)
Abstract: The activation and clonal expansion of naive T cells by antigen-loaded dendritic cells (DCs) in the lymph nodes is a key event during immune response. This activation involves the formation of a specialized cell-cell contact region, formed between a mature DC and a CD4 T cell, which is called immunological synapse (IS). The IS includes a DC and a T cell side that we call IS(DC) and IS(T cell), respectively. Most studies on the IS have focused on the IS(T cell) and the information gathered on the IS(DC) is sparse. However, lines of emerging evidence indicate that the IS(DC), likewise the IS(T cell), is a signaling and functional region that makes important contribution to T cell activation and immune response
Description: 5 p.
Publisher version (URL): http://www.discoverymedicine.com/Jose-Luis-Rodriguez-Fernandez/2009/10/07/the-dendritic-cell-side-of-the-immunological-synapse-exploring-terra-incognita/
URI: http://hdl.handle.net/10261/53548
ISSN: 1539-6509
E-ISSN: 1944-7930
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