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Title

Differential modulation of hepatic very low-density lipoprotein secretion by triacylglycerol-rich lipoproteins derived from different oleic-acid rich dietary oils

AuthorsPerona, Javier S. ; Avella, Michael; Botham, K. M.; Ruiz-Gutiérrez, Valentina
KeywordsTriacylglycerol-rich lipoprotein
VLDL
Liver
Virgin olive oil (VOO)
PPARα
Issue DateJan-2008
PublisherCambridge University Press
CitationBritish Journal of Nutrition 99(1): 29-36 (2008)
AbstractMinor components from dietary oils can modulate the atherogenic response of the TAG-rich lipoproteins (TRL) in which they are transported. In the present study we investigated the influence of TRL isolated from man after the intake of oleic acid-rich oils with different minor component compositions on VLDL secretion by rat primary hepatocytes. TRL were isolated from nine men after the intake of meals enriched with high-oleic sunflower oil (HOSO) or virgin olive oil (VOO) or VOO enriched with minor components (EVO). TRL were incubated with rat primary hepatocytes and the lipid accumulation was analysed in the cells and the secreted VLDL. The expression of genes for proteins related to hepatic lipid metabolism and VLDL production was also measured. Incubation of hepatocytes with TRL derived from HOSO as compared to VOO led to lower intracellular lipid accumulation and VLDL production despite higher mRNA expression for diacylglycerol-acyltransferase, microsomal TAG transfer protein, apoB and PPARα. When TRL derived from EVO were used there were no changes in VLDL secretion. These results suggest that incorporation of minor components from dietary high-oleic oils into TRL modulates the effect of these atherogenic particles on VLDL secretion. © 2007 The Authors.
URIhttp://hdl.handle.net/10261/53543
DOI10.1017/S0007114507793868
Identifiersdoi: 10.1017/S0007114507793868
issn: 0007-1145
e-issn: 1475-2662
ReferencesPMID: 17651518
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