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dc.contributor.authorSayanova, Olga-
dc.contributor.authorHaslam, Richard P.-
dc.contributor.authorVenegas-Calerón, Mónica-
dc.contributor.authorRuiz-López, Noemí-
dc.contributor.authorWorthy, Charlotte-
dc.contributor.authorRooks, Paul-
dc.contributor.authorAllen, Michael J.-
dc.contributor.authorNapier, Johnathan A.-
dc.identifierdoi: 10.1016/j.phytochem.2011.01.022-
dc.identifierissn: 0031-9422-
dc.identifier.citationPhytochemistry 72(7): 594-600 (2011)-
dc.description.abstractThe Prymnesiophyceae coccolithophore Emiliania huxleyi is one of the most abundant alga in our oceans and therefore plays a central role in marine foodwebs. E. huxleyi is notable for the synthesis and accumulation of the omega-3 long chain polyunsaturated fatty acid docosahexaenoic acid (DHA; 22:6Δ4,7,10,13,16,19, n - 3) which is accumulated in fish oils and known to have health-beneficial properties to humans, preventing cardiovascular disease and related pathologies. Here we describe the identification and functional characterisation of the five E. huxleyi genes which direct the synthesis of docosahexaenoic acid in this alga. Surprisingly, E. huxleyi does not use the conventional Δ6-pathway, instead using the alternative Δ8-desaturation route which has previously only been observed in a few unrelated microorganisms. Given that E. huxleyi accumulates significant levels of the Δ6-desaturated fatty acid stearidonic acid (18:4Δ6,9,12,15, n - 3), we infer that the biosynthesis of DHA is likely to be metabolically compartmentalised from the synthesis of stearidonic acid. © 2011 Elsevier Ltd. All rights reserved.-
dc.description.sponsorshipRothamsted Research receives grant-aided support from the BBSRC (UK). MJA receives support from the NERC (UK) through the Oceans 2025 programme. CW was supported by a BBSRC-CASE studentship jointly awarded to JAN and MJA.-
dc.subjectEmiliania huxleyl-
dc.subjectOmega-3 long chain polyunsaturated fatty acids-
dc.titleIdentification and functional characterisation of genes encoding the omega-3 polyunsaturated fatty acid biosynthetic pathway from the coccolithophore Emiliania huxleyi-
dc.description.versionPeer Reviewed-
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