Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/53254
Título : Mirror represses pipe expression in follicle cells to initiate dorsoventral axis formation in Drosophila
Autor : Andreu, María José, González-Pérez, Esther, Ajuria, Leiore, Samper, Núria, González-Crespo, Sergio, Campuzano, Sonsoles, Jiménez, Gerardo
Fecha de publicación : 2012
Editor: Company of Biologists
Citación : Development 139(6): 1110-1114 (2012)
Resumen: Dorsoventral (DV) axis formation in Drosophila begins with selective activation of EGFR, a receptor tyrosine kinase (RTK), in dorsal-anterior (DA) ovarian follicle cells. A critical event regulated by EGFR signaling is the repression of the sulfotransferase-encoding gene pipe in dorsal follicle cells, but how this occurs remains unclear. Here we show that Mirror (Mirr), a homeodomain transcription factor induced by EGFR signaling in DA follicle cells, directly represses pipe expression by binding to a conserved element in the pipe regulatory region. In addition, we find that the HMG-box protein Capicua (Cic) supports pipe expression in ventral follicle cells by repressing Mirr in this region. Interestingly, this role of Cic resembles its function in regulating anteroposterior (AP) body patterning, where Cic supports gap gene expression in central regions of the embryo by repressing Tailless, a repressor induced by RTK signaling at the embryonic poles. Thus, related RTK-Cic repressor circuits regulate the early stages of Drosophila DV and AP body axis formation. © 2012. Published by The Company of Biologists Ltd.
URI : http://hdl.handle.net/10261/53254
Identificadores: doi: 10.1242/dev.076562
issn: 0950-1991
e-issn: 1477-9129
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