Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/53069COMPARTIR / EXPORTAR:
 SHARE
 CORE
BASE
|
|
| Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.contributor.author | van Raaij, Mark J. | - |
| dc.contributor.author | Overhand, Mark | - |
| dc.date.accessioned | 2012-07-10T10:26:21Z | - |
| dc.date.available | 2012-07-10T10:26:21Z | - |
| dc.date.issued | 2010 | - |
| dc.identifier | doi: 10.1002/chem.200902984 | - |
| dc.identifier | issn: 0947-6539 | - |
| dc.identifier.citation | Chemistry - A European Journal 16(14): 4259-4265 (2010) | - |
| dc.identifier.uri | http://hdl.handle.net/10261/53069 | - |
| dc.description | et al. | - |
| dc.description.abstract | The cyclic decapeptide gramicidin S (GS) was used as a model for the evaluation of four turn mimetics. For this purpose, one of the D-Phe-Pro two-residue turn motifs in the rigid cyclic β-hairp0in structure of GS was replaced with morpholine amino acids (MAA 2-5), differing in stereochemistry and length of the side-chain. The conformational properties of the thus obtained GS analogues (6-9) was assessed by using NMR spectroscopy and X-ray crystallography, and correlated with their biological properties (antimicrobial and hemolytic activity). We show that compound 8, containing the dipeptide isostere trans-MAA 4, has an apparent high structural resemblance with GS and that its antibacterial activity against a panel of Gram positive and -negative bacterial strains is better than the derivatives 6, 7 and 9. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA. | - |
| dc.description.sponsorship | Este trabajo ha sido financiado por una beca del Leiden Institute of Chemistry y por la subvención BFU2008-01588/BMC del Ministerio español de Ciencia e Innovación. José M. Otero ha sido apoyado económicamente por un contratro “Angeles Alvariño” de la Xunta de Galicia. | - |
| dc.language.iso | eng | - |
| dc.publisher | Wiley-VCH | - |
| dc.rights | closedAccess | - |
| dc.title | Gramicidin S derivatives containing cis- and trans-morpholine amino acids (MAAS) as turn mimetics | - |
| dc.type | artículo | - |
| dc.identifier.doi | 10.1002/chem.200902984 | - |
| dc.date.updated | 2012-07-10T10:26:21Z | - |
| dc.description.version | Peer Reviewed | - |
| dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
| item.openairetype | artículo | - |
| item.grantfulltext | none | - |
| item.cerifentitytype | Publications | - |
| item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
| item.fulltext | No Fulltext | - |
| item.languageiso639-1 | en | - |
| Aparece en las colecciones: | (IBMB) Artículos | |
Ficheros en este ítem:
| Fichero | Descripción | Tamaño | Formato | |
|---|---|---|---|---|
| accesoRestringido.pdf | 15,38 kB | Adobe PDF |  Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
15
checked on 19-abr-2024
WEB OF SCIENCETM
Citations
14
checked on 27-feb-2024
Page view(s)
281
checked on 18-abr-2024
Download(s)
100
checked on 18-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.