Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/52956
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Schmid, Damaris | - |
dc.contributor.author | Messlinger, Karl | - |
dc.contributor.author | Belmonte, Carlos | - |
dc.contributor.author | Fischer, Michael J.M. | - |
dc.date.accessioned | 2012-07-09T07:49:59Z | - |
dc.date.available | 2012-07-09T07:49:59Z | - |
dc.date.issued | 2011 | - |
dc.identifier | doi: 10.1016/j.neulet.2010.11.022 | - |
dc.identifier | issn: 0304-3940 | - |
dc.identifier | e-issn: 1872-7972 | - |
dc.identifier.citation | Neuroscience Letters 488(2): 168-172 (2011) | - |
dc.identifier.uri | http://hdl.handle.net/10261/52956 | - |
dc.description.abstract | Nerve lesions are common injuries. While peripheral sensitivity is lost, the partially regenerating nerve undergoes a complex transformation, occasionally leading to persistent pain syndromes. Changes of thermal perception following nerve injury have received little attention. This study investigates the sensitivity of trigeminal neurons after infraorbital nerve lesion in guinea-pigs. Cultured trigeminal neurons innervating the area of denervation were identified by retrograde transport of DiI deposited at the site of the lesion. The standardized protocol consisted of cold and heat stimulation starting from body temperature as well as application of menthol and capsaicin, while activation was quantified by Fura-2-based calcium microfluorimetry. Compared to neurons from control animals, DiI-positive neurons were similar in the percentage and extend of the responses to menthol and capsaicin. However, DiI-positive neurons were less responsive to cold stimulation and had a lower cold threshold when compared to DiI-negative or control neurons. At the same time, DiI-positive neurons were more responsive to heat stimulation and had a lower heat threshold compared to control neurons. In summary, the percentage of trigeminal neurons responsive to thermal or chemical stimulation did not change after axotomy. However, thermal sensitivity of these neurons was altered. © 2010. | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier | - |
dc.rights | closedAccess | - |
dc.title | Altered thermal sensitivity in neurons injured by infraorbital nerve lesion | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1016/j.neulet.2010.11.022 | - |
dc.date.updated | 2012-07-09T07:49:59Z | - |
dc.description.version | Peer Reviewed | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
item.languageiso639-1 | en | - |
Aparece en las colecciones: | (IN) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
4
checked on 20-abr-2024
WEB OF SCIENCETM
Citations
4
checked on 27-feb-2024
Page view(s)
293
checked on 23-abr-2024
Download(s)
111
checked on 23-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.