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dc.contributor.authorLomba, Miguel-
dc.contributor.authorOriol, Luis-
dc.contributor.authorAlcalá, Rafael-
dc.contributor.authorSánchez-Somolinos, Carlos-
dc.contributor.authorGrazú, Valeria-
dc.contributor.authorSerrano, José Luis-
dc.contributor.authorFuente, Jesús M. de la-
dc.identifierdoi: 10.1002/mabi.201100123-
dc.identifierissn: 1616-5187-
dc.identifiere-issn: 1616-5195-
dc.identifier.citationMacromolecular Bioscience 11(11): 1505-1514 (2011)-
dc.description.abstractThe thiol-yne click chemistry reaction has been used for the in situ photocrosslinking of an aliphatic hyperbranched polyester. The biocompatibility of the resulting networks has been studied and marked cytotoxicity was not found for HeLa (human cervical carcinoma) tumoral cells and COS7 fibroblasts. The photoinduced thiol-yne process allows the generation of patterned structures with different geometries in films by DLW and these materials can be used as substrates for cell adhesion. The influence of the substrate geometry on cell adhesion has been studied by culturing cells onto these substrates and a preference for the photopatterned polymeric material can be seen in some of the structures by contrast phase microscopy. Actin and vinculin fluorescent staining revealed different adhesion behavior for HeLa cells and COS7 fibroblasts and this could be assigned to the different motility of cells. The thiol-yne photoreaction has proven to be an attractive approach for the preparation of micropatterned biomaterials.-
dc.description.sponsorshipThis work was supported by the Spanish MEC projects MAT2008-06522-C02 and CTQ2008-03739/PPQ, DGA project PI018/08, ARAID project for young scientists, CSIC project PIE 200960I168, and FEDER funding (EU). M. Lomba thanks the Gobierno de Aragón (Spain) for his PhD Grant. J. M. de la Fuente thanks ARAID for financial support.-
dc.titleIn situ photopolymerization of biomaterials by thiol-yne click chemistry-
dc.description.versionPeer Reviewed-
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