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Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/52648
Title: Efficient access to (1H)-isoindolin-1-one-3-carboxylic acid derivatives by orthopalladation and carbonylation of methyl arylglycinate substrates
Authors: Nieto, Sonia; Sayago, Francisco J.; Laborda, Pedro; Soler, Tatiana; Cativiela, Carlos; Urriolabeitia, Esteban P.
Issue Date: 2011
Publisher: Elsevier
Citation: Tetrahedron 67(23): 4185-4191 (2011)
Abstract: The orthopalladation of methyl arylglycinate derivatives has been studied. The reaction proceeds efficiently for different electron-withdrawing and electron-releasing substituents at the aryl ring. The carbonylation of the orthopalladated complexes affords, in a single step, substituted (1H)-isoindolin-1-one-3-carboxylates. These compounds constitute valuable synthetic intermediates and can be transformed diastereoselectively into octahydroisoindole-1-carboxylic acid derivatives, an important scaffold in the synthesis of many biologically active compounds. © 2011 Elsevier Ltd. All rights reserved.
URI: http://hdl.handle.net/10261/52648
DOI: 10.1016/j.tet.2011.04.064
Identifiers: doi: 10.1016/j.tet.2011.04.064
issn: 0040-4020
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