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http://hdl.handle.net/10261/52632
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Gangoiti, Patricia | - |
dc.contributor.author | Camacho, Luz | - |
dc.contributor.author | Arana, Lide | - |
dc.contributor.author | Ouro, Alberto | - |
dc.contributor.author | Granado, María H. | - |
dc.contributor.author | Brizuela, Leyre | - |
dc.contributor.author | Casas, Josefina | - |
dc.contributor.author | Fabriàs, Gemma | - |
dc.contributor.author | Abad, José Luis | - |
dc.contributor.author | Delgado Cirilo, Antonio | - |
dc.contributor.author | Gómez-Muñoz, Antonio | - |
dc.date.accessioned | 2012-07-02T11:06:17Z | - |
dc.date.available | 2012-07-02T11:06:17Z | - |
dc.date.issued | 2010 | - |
dc.identifier.citation | Progress in Lipid Research | es_ES |
dc.identifier.issn | 0163-7827 | - |
dc.identifier.uri | http://hdl.handle.net/10261/52632 | - |
dc.description.abstract | Simple bioactive sphingolipids include ceramide, sphingosine and their phosphorylated forms sphingosine 1-phosphate and ceramide 1-phosphate. These molecules are crucial regulators of cell functions. In particular, they play important roles in the regulation of angiogenesis, apoptosis, cell proliferation, differentiation, migration, and inflammation. Decoding the mechanisms by which these cellular functions are regulated requires detailed understanding of the signaling pathways that are implicated in these processes. Most importantly, the development of inhibitors of the enzymes involved in their metabolism may be crucial for establishing new therapeutic strategies for treatment of disease. | es_ES |
dc.description.sponsorship | Current work in A.G.M. laboratory is supported by Grants BFU2009-13314/BMC from “Ministerio de Ciencia e Innovación”, GIC07/63-IT-311-07 from “Departamento de Educación, Universidades e Investigación del Gobierno Vasco, S-PE08UN37 from “Departamento de Industria, Comercio y Turismo del Gobierno Vasco”, and Fundación Ramón Areces (Spain). Work in CID-CSIC is supported by Grants SAF2008-00706 and CTQ2008-01426/BQU from “Ministerio de Ciencia e Innovación”, 2009SGR-01063 (predoctoral fellowship to L.C.) and 2009SGR-1072 from “Generalitat de Catalunya” (Spain). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.rights | closedAccess | es_ES |
dc.subject | Apoptosis | es_ES |
dc.subject | Cell proliferation | es_ES |
dc.subject | Ceramides | es_ES |
dc.subject | Ceramide kinase | es_ES |
dc.subject | Ceramide-1-phosphate | es_ES |
dc.subject | Ceramidases | es_ES |
dc.subject | Sphingosine kinase | es_ES |
dc.subject | Inflammation | es_ES |
dc.subject | Migration | es_ES |
dc.subject | Sphingolipids | es_ES |
dc.subject | Sphingosine 1-phosphate | es_ES |
dc.subject | Sphingomyelinases | es_ES |
dc.title | Control of metabolism and signaling of simple bioactive sphingolipids: Implications in disease | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1016/j.plipres.2010.02.004 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.1016/j.plipres.2010.02.004 | es_ES |
dc.identifier.e-issn | 1873-2194 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
item.languageiso639-1 | en | - |
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