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Title: Control of metabolism and signaling of simple bioactive sphingolipids: Implications in disease
Authors: Gangoiti, Patricia; Camacho, Luz; Arana, Lide; Ouro, Alberto; Granado, María H.; Brizuela, Leyre; Casas, Josefina; Fabriàs, Gemma; Abad, José Luis; Delgado, Antonio; Gómez-Muñoz, Antonio
Keywords: Apoptosis
Cell proliferation
Ceramides
Ceramide kinase
Ceramide-1-phosphate
Ceramidases
Sphingosine kinase
Inflammation
Migration
Sphingolipids
Sphingosine 1-phosphate
Sphingomyelinases
Issue Date: 2010
Publisher: Elsevier
Citation: Progress in Lipid Research
Abstract: Simple bioactive sphingolipids include ceramide, sphingosine and their phosphorylated forms sphingosine 1-phosphate and ceramide 1-phosphate. These molecules are crucial regulators of cell functions. In particular, they play important roles in the regulation of angiogenesis, apoptosis, cell proliferation, differentiation, migration, and inflammation. Decoding the mechanisms by which these cellular functions are regulated requires detailed understanding of the signaling pathways that are implicated in these processes. Most importantly, the development of inhibitors of the enzymes involved in their metabolism may be crucial for establishing new therapeutic strategies for treatment of disease.
Publisher version (URL): http://dx.doi.org/10.1016/j.plipres.2010.02.004
URI: http://hdl.handle.net/10261/52632
DOI: 10.1016/j.plipres.2010.02.004
ISSN: 0163-7827
10.1016/j.plipres.2010.02.004
E-ISSN: 1873-2194
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