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Título: | The transcription factor Krox20 is an E3 ligase that sumoylates its Nab coregulators |
Autor: | García-Gutiérrez, Pablo CSIC; Juárez-Vicente, Francisco CSIC ORCID; Gallardo-Chamizo, Francisco CSIC; Charnay, Patrick; García-Domínguez, Mario CSIC ORCID | Palabras clave: | Krox20 Nab SUMO ligase Ubc9 |
Fecha de publicación: | 3-sep-2011 | Editor: | Nature Publishing Group | Citación: | EMBO Reports 12(10): 1018-1023 (2011) | Resumen: | Covalent attachment of small ubiquitin-like modifier (SUMO) to proteins regulates many processes in the eukaryotic cell. This reaction is similar to ubiquitination and usually requires an E3 ligase for substrate modification. However, only a few SUMO ligases have been described so far, which frequently facilitate sumoylation by bringing together the SUMO-conjugating enzyme Ubc9 and the target protein. Ubc9 is an interaction partner of the transcription factor Krox20, a key regulator of hindbrain development. Here, we show that Krox20 functions as a SUMO ligase for its coregulators-the Nab proteins-and that Nab sumoylation negatively modulates Krox20 transcriptional activity in vivo. © 2011 EuropeEan MoleEcular Biology Oorganization. | Versión del editor: | http://dx.doi.org/10.1038/embor.2011.152 | URI: | http://hdl.handle.net/10261/52347 | DOI: | 10.1038/embor.2011.152 | Identificadores: | issn: 1469-221X |
Aparece en las colecciones: | (CABIMER) Artículos |
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Nab coregulators.pdf | 1,53 MB | Adobe PDF | Visualizar/Abrir |
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