Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/52165
Título : Access to the cis-fused stereoisomers of proline analogues containing an octahydroindole core
Autor : Sayago, Francisco J., Laborda, Pedro, Calaza, M. Isabel, Jiménez, Ana I., Cativiela, Carlos
Fecha de publicación : 2011
Editor: Wiley-VCH
Citación : European Journal of Organic Chemistry 11: 2011-2028 (2011)
Resumen: An overview of the synthetic methods developed to build all the cis-fused stereoisomers of octahydroindole-2-carboxylic acid and its α-methylated derivative in enantiomerically pure form is presented. Both asymmetric synthetic strategies(auxiliary- or substrate-controlled processes) and procedures based on the resolution of racemic compounds (chemical, enzymatic, and chromatographic processes) are summarized. Special emphasis has been placed on those strategies able to provide multigram quantities of enantiopure compounds, a prerequisite to make downstream biological applications feasible.
Descripción : El pdf del artículo es la versión post-print.
Versión del editor: http://dx.doi.org/10.1002/ejoc.201001710
URI : http://hdl.handle.net/10261/52165
Identificadores: doi: 10.1002/ejoc.201001710
issn: 1434-193X
e-issn: 1099-0690
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