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Open Access item Access to the cis-fused stereoisomers of proline analogues containing an octahydroindole core

Authors:Sayago, Francisco J.
Laborda, Pedro
Calaza, M. Isabel
Jiménez, Ana I.
Cativiela, Carlos
Issue Date:2011
Citation:European Journal of Organic Chemistry 11: 2011-2028 (2011)
Abstract:An overview of the synthetic methods developed to build all the cis-fused stereoisomers of octahydroindole-2-carboxylic acid and its α-methylated derivative in enantiomerically pure form is presented. Both asymmetric synthetic strategies(auxiliary- or substrate-controlled processes) and procedures based on the resolution of racemic compounds (chemical, enzymatic, and chromatographic processes) are summarized. Special emphasis has been placed on those strategies able to provide multigram quantities of enantiopure compounds, a prerequisite to make downstream biological applications feasible.
Description:El pdf del artículo es la versión post-print.
Publisher version (URL):http://dx.doi.org/10.1002/ejoc.201001710
Identifiers:doi: 10.1002/ejoc.201001710
issn: 1434-193X
e-issn: 1099-0690
Appears in Collections:(ICMA) Artículos

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