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dc.contributor.authorMarco, J. Alberto-
dc.contributor.authorGarcía-Pla, Jorge-
dc.contributor.authorCarda, Miguel-
dc.contributor.authorMurga, Juan-
dc.contributor.authorFalomir, Eva-
dc.contributor.authorTrigili, Chiara-
dc.contributor.authorNotararigo, Sara-
dc.contributor.authorDíaz, José Fernando-
dc.contributor.authorBarasoain, Isabel-
dc.date.accessioned2012-06-19T11:03:47Z-
dc.date.available2012-06-19T11:03:47Z-
dc.date.issued2011-05-
dc.identifier.citationEuropean Journal of Medicinal Chemistry 46(5):1630-1637(2011)es_ES
dc.identifier.issn0223-5234-
dc.identifier.urihttp://hdl.handle.net/10261/51844-
dc.description8 páginas, 4 figuras, 1 tabla, 2 esquemas -- PAGS nros. 1630-1637es_ES
dc.description.abstractThe preparation of a series of pironetin analogues with simplified structure is described. Their cytotoxic activity and their interactions with tubulin have been investigated. It has been found that, while less active than the parent molecule, the pironetin analogues still share the mechanism of action of the latter and compete for the same binding site to α-tubulin. Variations in the configurations of their stereocenters do not translate into relevant differences between biological activitieses_ES
dc.description.sponsorshipFinancial support has been granted by the Spanish Ministry of Education and Science (CTQ2008-02800), by the Consellería d'Empresa, Universitat i Ciencia de la Generalitat Valenciana (ACOMP09/113) and by the BANCAJA-UJI Foundation (P1-1B2002-06 and P1-1B-2008-14). The biological work has been supported in part by grants from the Spanish Ministry of Education and Science (BIO2007-61336 and BIO2010-16351) and from the Comunidad de Madrid (BIPPED-CM) (both to J.F.D.)es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.rightsclosedAccesses_ES
dc.subjectTubulines_ES
dc.subjectTubulin-active compoundes_ES
dc.subjectMicrotubule destabilizationes_ES
dc.subjectPironetin analoguees_ES
dc.subjectCytotoxicityes_ES
dc.titleDesign and Synthesis of Pironetin Analogues with Simplified Structure and Study of Their Interactions with Microtubuleses_ES
dc.typeartículoes_ES
dc.identifier.doi10.1016/j.ejmech.2011.02.011-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttp://dx.doi.org/10.1016/j.ejmech.2011.02.011es_ES
dc.identifier.e-issn1768-3254-
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es_ES
item.fulltextNo Fulltext-
item.openairetypeartículo-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.languageiso639-1en-
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