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Título : Design and Synthesis of Pironetin Analogues with Simplified Structure and Study of Their Interactions with Microtubules
Autor : Marco, J. Alberto, García-Plab, Jorge, Carda, Miguel, Murga, Juan, Falomir, Eva, Trigili, Chiara, Notararigo, Sara, Díaz, José Fernando, Barasoain, Isabel
Palabras clave : Tubulin
Tubulin-active compound
Microtubule destabilization
Pironetin analogue
Fecha de publicación : May-2011
Editor: Elsevier
Resumen: The preparation of a series of pironetin analogues with simplified structure is described. Their cytotoxic activity and their interactions with tubulin have been investigated. It has been found that, while less active than the parent molecule, the pironetin analogues still share the mechanism of action of the latter and compete for the same binding site to α-tubulin. Variations in the configurations of their stereocenters do not translate into relevant differences between biological activities
Descripción : 8 páginas, 4 figuras, 1 tabla, 2 esquemas -- PAGS nros. 1630-1637
Versión del editor:
ISSN: 0223-5234
DOI: 10.1016/j.ejmech.2011.02.011
Citación : European Journal of Medicinal Chemistry 46(5):1630-1637(2011)
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