English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/51844
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Design and Synthesis of Pironetin Analogues with Simplified Structure and Study of Their Interactions with Microtubules

AuthorsMarco, J. Alberto; García-Plab, Jorge; Carda, Miguel; Murga, Juan; Falomir, Eva; Trigili, Chiara ; Notararigo, Sara ; Díaz, José Fernando ; Barasoain, Isabel
KeywordsTubulin
Tubulin-active compound
Microtubule destabilization
Pironetin analogue
Cytotoxicity
Issue DateMay-2011
PublisherElsevier
CitationEuropean Journal of Medicinal Chemistry 46(5):1630-1637(2011)
AbstractThe preparation of a series of pironetin analogues with simplified structure is described. Their cytotoxic activity and their interactions with tubulin have been investigated. It has been found that, while less active than the parent molecule, the pironetin analogues still share the mechanism of action of the latter and compete for the same binding site to α-tubulin. Variations in the configurations of their stereocenters do not translate into relevant differences between biological activities
Description8 páginas, 4 figuras, 1 tabla, 2 esquemas -- PAGS nros. 1630-1637
Publisher version (URL)http://dx.doi.org/10.1016/j.ejmech.2011.02.011
URIhttp://hdl.handle.net/10261/51844
DOI10.1016/j.ejmech.2011.02.011
ISSN0223-5234
E-ISSN1768-3254
Appears in Collections:(CIB) Artículos
Files in This Item:
There are no files associated with this item.
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.