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Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/51844
Title: Design and Synthesis of Pironetin Analogues with Simplified Structure and Study of Their Interactions with Microtubules
Authors: Marco, J. Alberto; García-Plab, Jorge; Carda, Miguel; Murga, Juan; Falomir, Eva; Trigili, Chiara; Notararigo, Sara; Díaz, José Fernando; Barasoain, Isabel
Keywords: Tubulin
Tubulin-active compound
Microtubule destabilization
Pironetin analogue
Issue Date: May-2011
Publisher: Elsevier
Citation: European Journal of Medicinal Chemistry 46(5):1630-1637(2011)
Abstract: The preparation of a series of pironetin analogues with simplified structure is described. Their cytotoxic activity and their interactions with tubulin have been investigated. It has been found that, while less active than the parent molecule, the pironetin analogues still share the mechanism of action of the latter and compete for the same binding site to α-tubulin. Variations in the configurations of their stereocenters do not translate into relevant differences between biological activities
Description: 8 páginas, 4 figuras, 1 tabla, 2 esquemas -- PAGS nros. 1630-1637
Publisher version (URL): http://dx.doi.org/10.1016/j.ejmech.2011.02.011
URI: http://hdl.handle.net/10261/51844
DOI: 10.1016/j.ejmech.2011.02.011
ISSN: 0223-5234
E-ISSN: 1768-3254
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