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Membrane-associated nanomotors for macromolecular transport

AuthorsCabezón, Elena ; Lanza, Val F. ; Arechaga, Ignacio
Issue Date2011
CitationCurrent Opinion in Biotechnology 23(4): 1-8 (2011)
AbstractNature has endowed cells with powerful nanomotors to accomplish intricate mechanical tasks, such as the macromolecular transport across membranes occurring in cell division, bacterial conjugation, and in a wide variety of secretion systems. These biological motors couple the chemical energy provided by ATP hydrolysis to the mechanical work needed to transport DNA and/or protein effectors. Here, we review what is known about the molecular mechanisms of these membrane-associated machines. Sequence and structural comparison between these ATPases reveal that they share a similar motor domain, suggesting a common evolutionary ancestor. Learning how these machines operate will lead the design of nanotechnology devices with unique applications in medicine and engineering.
Identifiersdoi: 10.1016/j.copbio.2011.11.031
issn: 0958-1669
Appears in Collections:(IBBTEC) Artículos
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