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Título: | Membrane-associated nanomotors for macromolecular transport |
Autor: | Cabezón, Elena CSIC ORCID; Lanza, Val F. CSIC; Arechaga, Ignacio CSIC ORCID | Fecha de publicación: | 2011 | Editor: | Elsevier | Citación: | Current Opinion in Biotechnology 23(4): 1-8 (2011) | Resumen: | Nature has endowed cells with powerful nanomotors to accomplish intricate mechanical tasks, such as the macromolecular transport across membranes occurring in cell division, bacterial conjugation, and in a wide variety of secretion systems. These biological motors couple the chemical energy provided by ATP hydrolysis to the mechanical work needed to transport DNA and/or protein effectors. Here, we review what is known about the molecular mechanisms of these membrane-associated machines. Sequence and structural comparison between these ATPases reveal that they share a similar motor domain, suggesting a common evolutionary ancestor. Learning how these machines operate will lead the design of nanotechnology devices with unique applications in medicine and engineering. | URI: | http://hdl.handle.net/10261/51828 | DOI: | 10.1016/j.copbio.2011.11.031 | Identificadores: | doi: 10.1016/j.copbio.2011.11.031 issn: 0958-1669 |
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