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Title

Control of the function of the transcription and repair factor TFIIH by the action of the cochaperone Ydj1

AuthorsMoriel-Carretero, María ; Tous, Cristina ; Aguilera, Andrés
KeywordsRad3/XPD
Xeroderma pigmentosum
Cockayne syndrome
Genome instability
HDJ-2
Issue Date12-Sep-2011
PublisherNational Academy of Sciences (U.S.)
CitationProceedings of the National Academy of Sciences of the United States of America 108(37): 15300-15305 (2011)
AbstractYeast rad3-102, a mutant of the TFIIH complex involved in nucleotide excision repair (NER) and transcription, can perform NER initial steps but not late steps of postincision gap filing. Because removal of early-acting NER proteins prevents rad3-102 deleterious action, we used this feature to explore if chaperones act in early NER. We found that the cochaperone Ydj1 is required for NER and that Ydj1 guarantees TFIIH stoichiometry. Importantly, in the absence of Ydj1, the roles of TFIIH in transcription and transactivation, the ability to activate transcription by nuclear receptors in response to hormones, are strongly impaired. We propose that TFIIH constitutes a multitarget complex for Ydj1, as six of the seven TFIIH core components contain biologically relevant Ydj1- binding motives. Our results provide evidence for a role of chaperones in NER and transcription, with implications in cancer and TFIIH-associated syndromes.
URIhttp://hdl.handle.net/10261/51079
DOI10.1073/pnas.1107425108
Identifiersissn: 0027-8424
e-issn: 1091-6490
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