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Open Access item Reductive genome evolution in Buchnera aphidicola

Authors:Ham, Roeland C.H.J. van
Kamerbeek, Judith
Palacios, Carmen
Rausell, Carolina
Abascal, Federico
Bastolla, Ugo
Fernández, José M.
Jiménez, Luis
Postigo, Marina
Silva-Moreno, Francisco
Tamames, Javier
Viguera, Enrique
Latorre-Castillo, Amparo
Valencia, Alfonso
Morán, Federico
Moya-Simarro, Andrés
Issue Date:Jan-2003
Publisher:National Academy of Sciences (U.S.)
Citation:Proc Natl Acad Sci U S A. 2003 January 21; 100(2): 581–586
Abstract:We have sequenced the genome of the intracellular symbiont Buchnera aphidicola from the aphid Baizongia pistacea. This strain diverged 80–150 million years ago from the common ancestor of two previously sequenced Buchnera strains. Here, a field-collected, nonclonal sample of insects was used as source material for laboratory procedures. As a consequence, the genome assembly unveiled intrapopulational variation, consisting of ≈1,200 polymorphic sites. Comparison of the 618-kb (kbp) genome with the two other Buchnera genomes revealed a nearly perfect gene-order conservation, indicating that the onset of genomic stasis coincided closely with establishment of the symbiosis with aphids, ≈200 million years ago. Extensive genome reduction also predates the synchronous diversification of Buchnera and its host; but, at a slower rate, gene loss continues among the extant lineages. A computational study of protein folding predicts that proteins in Buchnera, as well as proteins of other intracellular bacteria, are generally characterized by smaller folding efficiency compared with proteins of free living bacteria. These and other degenerative genomic features are discussed in light of compensatory processes and theoretical predictions on the long-term evolutionary fate of symbionts like Buchnera.
Description:Copyright © by National Academy of Sciences.-- La versión original está disponible en http://www.pnas.org/.-- Supplementary material available at: http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=141039#supplementary-material-sec
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