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Open Access item The apical ectodermal ridge: morphological aspects and signaling pathways

Authors:Fernandez-Teran, Marian
Ros, María A.
Issue Date:2008
Publisher:Universidad del País Vasco
Citation:International Journal of Developmental Biology 52: 857-871 (2008)
Abstract:The Apical Ectodermal Ridge (AER) is one of the main signaling centers during limb development. It controls outgrowth and patterning in the proximo-distal axis. In the last few years a considerable amount of new data regarding the cellular and molecular mechanisms underlying AER function and structure has been obtained. In this review, we describe and discuss current knowledge of the regulatory networks which control the induction, maturation and regression of the AER, as well as the link between dorso-ventral patterning and the formation and position of the AER. Our aim is to integrate both recent and old knowledge to produce a wider picture of the AER which enhances our understanding of this relevant structure. © UBC Press.
Publisher version (URL):http://dx.doi.org/10.1387/ijdb.072416mf
Identifiers:doi: 10.1387/ijdb.072416mf
issn: 0214-6282
Appears in Collections:(IBBTEC) Artículos

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