English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/49928
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:


Laforin and malin deletions in mice produce similar neurologic impairments

AuthorsGarcía-Cabrero, Ana M.; Marinas, Ainhoa; Guerrero, Rosa; Rodríguez de Córdoba, Santiago ; Serratosa, José María; Sánchez, Marina P.
KeywordsAnimal models
Progressive myoclonus epilepsy
Issue Date1-May-2012
PublisherLippincott Williams & Wilkins
CitationJournal of Neuropathology and Experimental Neurology,71:413-421(2012)
AbstractLafora disease is a progressive myoclonus epilepsy caused by mutations in the EPM2A gene encoding laforin or in the EPM2B gene encoding malin. It is characterized by the presence of polyglucosan intracellular inclusion bodies (Lafora bodies) in brain and other tissues. Targeted disruption of Epm2a or Epm2b genes in mice produced widespread neuronal degeneration and accumulation of Lafora bodies in neuronal and nonneuronal tissues. Here we analyzed the neurologic alterations produced by disruption of the laforin gene in Epm2a−/− mice and compared them to those in malin-deficient mice. Both Epm2a−/− and Epm2b−/− mice showed altered motor activity, impaired motor coordination, abnormal hind limb clasping, and episodic memory deficits. Epm2a−/− mice also had tonic-clonic seizures, whereas both Epm2a−/− and Epm2b−/− mice had spontaneous single spikes, spike-wave, polyspikes, and polyspike-wave complexes with correlated myoclonic jerks. Neurologic alterations observed in the mutants were comparable and correlated with the accumulation of abundant Lafora bodies in the cerebral cortex, the hippocampus, the basal ganglia, the cerebellum, and the brainstem, suggesting that these inclusions could cause cognitive and behavioral deterioration. Thus, both Epm2a−/− and Epm2b−/− mice exhibit many pathologic aspects seen in patients with Lafora disease and may be valuable for the study of this disorder
Description9 páginas
Publisher version (URL)http://dx.doi.org/ 10.1097/NEN.0b013e318253350f
Appears in Collections:(CIB) Artículos
Files in This Item:
File Description SizeFormat 
restringido.pdf21,67 kBAdobe PDFThumbnail
Show full item record
Review this work

Related articles:

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.