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Closed Access item Tubulin Binding, Protein-Bound Conformation in Solution, and Antimitotic Cellular Profiling of Noscapine and Its Derivatives

Authors:Bennani, Y. L.
Gu, W.
Canales Mayordomo, María Ángeles
Díaz, José Fernando
Eustace, B.K.
Hoover, R.R.
Jiménez-Barbero, Jesús
Nezami, A.
Wang, T.
Issue Date:9-Feb-2012
Publisher:American Chemical Society
Citation:Journal of Medicinal Chemistry, 55 (5) : 1920-1925 (2012)
Abstract:Noscapine and its 7-hydroxy and 7-amino derivatives were characterized for their binding to tubulin. A solution NMR structure of these compounds bound to tubulin shows that noscapine and its 7-aniline derivative do not compete for the same binding site nor does its small molecule crystal structure match its tubulin-bound conformation. These compounds were also tested for their antiproliferative effects on a panel hepatocellular carcinoma cell lines
Description:6 páginas, 9 figuras, 3 tablas -- PAGS nros. 1920-1925
Publisher version (URL):http://dx.doi.org./10.1021/jm200848t
URI:http://hdl.handle.net/10261/49900
ISSN:0022-2623
E-ISSNmetadata.dc.identifier.doi = DOI:1520-4804
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Appears in Collections:(CIB) Artículos

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