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Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/49900
Title: Tubulin Binding, Protein-Bound Conformation in Solution, and Antimitotic Cellular Profiling of Noscapine and Its Derivatives
Authors: Bennani, Y. L.; Gu, W.; Canales, Ángeles; Díaz, José Fernando; Eustace, B.K.; Hoover, R.R.; Jiménez-Barbero, Jesús; Nezami, A.; Wang, T.
Issue Date: 9-Feb-2012
Publisher: American Chemical Society
Citation: Journal of Medicinal Chemistry, 55 (5) : 1920-1925 (2012)
Abstract: Noscapine and its 7-hydroxy and 7-amino derivatives were characterized for their binding to tubulin. A solution NMR structure of these compounds bound to tubulin shows that noscapine and its 7-aniline derivative do not compete for the same binding site nor does its small molecule crystal structure match its tubulin-bound conformation. These compounds were also tested for their antiproliferative effects on a panel hepatocellular carcinoma cell lines
Description: 6 páginas, 9 figuras, 3 tablas -- PAGS nros. 1920-1925
Publisher version (URL): http://dx.doi.org./10.1021/jm200848t
ISSN: 0022-2623
DOI: 10.1021/jm200848t
E-ISSN: 1520-4804
Appears in Collections:(CIB) Artículos
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