Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/49900
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Título : Tubulin Binding, Protein-Bound Conformation in Solution, and Antimitotic Cellular Profiling of Noscapine and Its Derivatives
Autor : Bennani, Y. L., Gu, W., Canales Mayordomo, María Ángeles, Díaz, José Fernando, Eustace, B.K., Hoover, R.R., Jiménez-Barbero, Jesús, Nezami, A., Wang, T.
Fecha de publicación : 9-Feb-2012
Editor: American Chemical Society
Citación : Journal of Medicinal Chemistry, 55 (5) : 1920-1925 (2012)
Resumen: Noscapine and its 7-hydroxy and 7-amino derivatives were characterized for their binding to tubulin. A solution NMR structure of these compounds bound to tubulin shows that noscapine and its 7-aniline derivative do not compete for the same binding site nor does its small molecule crystal structure match its tubulin-bound conformation. These compounds were also tested for their antiproliferative effects on a panel hepatocellular carcinoma cell lines
Descripción : 6 páginas, 9 figuras, 3 tablas -- PAGS nros. 1920-1925
Versión del editor: http://dx.doi.org./10.1021/jm200848t
URI : http://hdl.handle.net/10261/49900
ISSN: 0022-2623
DOI: 10.1021/jm200848t
Citación : Journal of Medicinal Chemistry, 55 (5) : 1920-1925 (2012)
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