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dc.contributor.authorValderrama, J. Andrés-
dc.contributor.authorDurante-Rodríguez, Gonzalo-
dc.contributor.authorBlázquez, Blas-
dc.contributor.authorGarcía, José Luis-
dc.contributor.authorCarmona, Manuel-
dc.contributor.authorDíaz, Eduardo-
dc.date.accessioned2012-05-21T09:07:31Z-
dc.date.available2012-05-21T09:07:31Z-
dc.date.issued2012-02-02-
dc.identifier.citationJournal of Biological Chemistry 287:10494-10508 (2012)es_ES
dc.identifier.issn0021-9258-
dc.identifier.urihttp://hdl.handle.net/10261/49890-
dc.description22 p.- 9 fig.-2 tab.-4 fig. supl.es_ES
dc.description.abstractWe have studied for the first time the transcriptional regulatory circuit that controls the expression of the box genes encoding the aerobic hybrid pathway used to assimilate benzoate via coenzyme A (CoA) derivatives in bacteria. The promoters responsible for the expression of the box cluster in the β-proteobacterium Azoarcus sp., their cognate transcriptional repressor, the BoxR protein, and the inducer molecule (benzoyl-CoA) have been characterized. The BoxR protein shows a significant sequence identity to the BzdR transcriptional repressor that controls the bzd genes involved in the anaerobic degradation of benzoate. Because the boxR gene is present in all box clusters so far identified in bacteria, the BoxR/benzoyl-CoA regulatory system appears to be a widespread strategy to control this aerobic hybrid pathway. Interestingly, the paralogous BoxR and BzdR regulators act synergistically to control the expression of the box and bzd genes. This cross-regulation between anaerobic and aerobic pathways for the catabolism of aromatic compounds has never been shown before, and it may reflect a biological strategy to increase the cell fitness in organisms that survive in environments subject to changing oxygen concentrationses_ES
dc.description.sponsorshipThis work was supported by grants BIO2009-10438 and CSD2007-00005 from the Comisión Interministerial de Ciencia y Tecnologíaes_ES
dc.language.isoenges_ES
dc.publisherAmerican Society for Biochemistry and Molecular Biologyes_ES
dc.rightsopenAccesses_ES
dc.subjectBacterial Transcriptiones_ES
dc.subjectBiodegradationes_ES
dc.subjectGene Regulationes_ES
dc.subjectMicrobiologyes_ES
dc.subjectMolecular biologyes_ES
dc.subjectTranscriptiones_ES
dc.subjectRegulation Azoarcuses_ES
dc.subjectBenzoyl-CoAes_ES
dc.titleBacterial degradation of benzoate: cross-regulation between aerobic and anaerobic pathwayses_ES
dc.typeartículoes_ES
dc.identifier.doi10.1074/jbc.M111.309005-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttp://dx.doi.org/ 10.1074/jbc.M111.309005es_ES
dc.identifier.e-issn1083-351X-
dc.embargo.terms2013-02-02es_ES
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