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A Trypanosoma cruzi monoclonal antibody that recognizes a superficial tubulin-like antigen

AuthorsAlcina, Antonio; Hargreaves, A. J.; Ávila, Jesús ; Fresno, Manuel
Issue Date1986
PublisherAcademic Press
CitationBiochemical and Biophysical Research Communications 139: 1176-1183 (1986)
AbstractA monoclonal antibody (MAB 10), obtained from mice infected with Trypanosoma cruzi, was found to recognize a superficial antigen in living or fixed parasites. It reacted more strongly with T. cruzi than with related parasites such as T. brucei and Leishmania. In immunoblots it recognized a single trypanosoma polypeptide and also brain tubulin, both of which had the same electrophoretic mobility. Further analysis suggested that the α-tubulin subunit contained the epitope recognized by MAB 10. These results suggest that a surface tubulin-like protein is present in T. cruzi.
Identifiersissn: 0006-291X
Appears in Collections:(CBM) Artículos
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