Please use this identifier to cite or link to this item:
http://hdl.handle.net/10261/49783Share/Export:
 SHARE
 CORE
BASE
|
|
| Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
| Title: | Role of Epiprofin, a zinc-finger transcription factor, in limb development |
Authors: | Delgado, Irene CSIC; Ros, María A. CSIC ORCID | Keywords: | Epiprofin Sp6 |
Issue Date: | 15-Jan-2010 | Publisher: | Elsevier | Citation: | Developmental Biology 337(2): 363–374 (2010) | Abstract: | The formation and maintenance of the apical ectodermal ridge (AER) is critical for the outgrowth and patterning of the vertebrate limb. In the present work, we have investigated the role of Epiprofin (Epfn/Sp6), a member of the SP/KLF transcription factor family that is expressed in the limb ectoderm and the AER, during limb development. Epfn mutant mice have a defective autopod that shows mesoaxial syndactyly in the forelimb and synostosis (bony fusion) in the hindlimb and partial bidorsal digital tips. Epfn mutants also show a defect in the maturation of the AER that appears flat and broad, with a double ridge phenotype. By genetic analysis, we also show that Epfn is controlled by WNT/b-CATENIN signaling in the limb ectoderm. Since the less severe phenotypes of the conditional removal of b-catenin in the limb ectoderm strongly resemble the limb phenotype of Epfn mutants, we propose that EPFN very likely functions as a modulator of WNT signaling in the limb ectoderm. | Description: | El pdf del artículo es el manuscrito de autor (PMCID: PMC3538143).-- et al. | Publisher version (URL): | http://dx.doi.org/10.1016/j.ydbio.2009.11.007 | URI: | http://hdl.handle.net/10261/49783 | DOI: | 10.1016/j.ydbio.2009.11.007 | ISSN: | 0012-1606 |
| Appears in Collections: | (IBBTEC) Artículos |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Role of Epiprofin.pdf | 3,39 MB | Adobe PDF |  View/Open |
CORE Recommender
PubMed Central
Citations
15
checked on Apr 9, 2024
SCOPUSTM
Citations
29
checked on Apr 19, 2024
WEB OF SCIENCETM
Citations
24
checked on Feb 28, 2024
Page view(s)
309
checked on Apr 23, 2024
Download(s)
356
checked on Apr 23, 2024
Google ScholarTM
Check
Altmetric
Altmetric
Related articles:
WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.