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http://hdl.handle.net/10261/49756
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Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Miguel, Marta | - |
dc.contributor.author | Gómez-Ruiz, José Ángel | - |
dc.contributor.author | Recio, Isidra | - |
dc.contributor.author | Aleixandre, Amaya | - |
dc.date.accessioned | 2012-05-16T12:34:36Z | - |
dc.date.available | 2012-05-16T12:34:36Z | - |
dc.date.issued | 2010-10 | - |
dc.identifier.citation | Molecular Nutrition and Food Research 54(10): 1422-1427 (2010) | es_ES |
dc.identifier.issn | 1613-4125 | - |
dc.identifier.uri | http://hdl.handle.net/10261/49756 | - |
dc.description | 6 páginas, 3 figuras, 1 tabla. | es_ES |
dc.description.abstract | In this study we evaluated the short-term oral antihypertensive effect of several peptide sequences isolated from casein fractions, previously characterized as in vitro angiotensin-converting enzyme-inhibitors, in spontaneously hypertensive rats (SHR). Systolic blood pressure (SBP) and the diastolic blood pressure (DBP) of the rats were measured by the tail cuff method before administration and also 2, 4, 6, 8 and 24 h post-administration. The sequences LVYPFTGPIPN, HLPLP, IAK, YAKPVA and WQVLPNAVPAK showed a clear decrease in SBP and DBP in SHR. HPHPHLSF caused a significant decrease of the DBP in the SHR, but this sequence did not modify the SBP of these animals in a significant manner. KKYNVPQL did not modify SBP in the SHR, and caused a slight, but significant and maintained, decrease in DBP in these animals. SBP and DBP returned to baseline values 24 h post-administration of all peptides. In conclusion, these peptides are bioactive ingredients with potential benefit in the prevention and treatment of hypertension or other associated disorders. | es_ES |
dc.description.sponsorship | This study has received financial support from the projects AGL2007-65035, AGL2008-01713 and CSD-2007-00063. Marta Miguel is the recipient of a Ramón y Cajal contract from MICINN. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Wiley-VCH | es_ES |
dc.rights | closedAccess | es_ES |
dc.subject | Angiotensin converting enzyme inhibitory activity | es_ES |
dc.subject | Food peptides | es_ES |
dc.subject | Hypertension | es_ES |
dc.subject | Milk proteins | es_ES |
dc.subject | Spontaneously hypertensive rats | es_ES |
dc.title | Changes in arterial blood pressure after single oral administration of milk-casein-derived peptides in spontaneously hypertensive rats | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1002/mnfr.200900448 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.1002/mnfr.200900448 | es_ES |
dc.identifier.e-issn | 1613-4133 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
item.languageiso639-1 | en | - |
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accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
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