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Title

Changes in arterial blood pressure after single oral administration of milk-casein-derived peptides in spontaneously hypertensive rats

AuthorsMiguel, Marta ; Gómez-Ruiz, José Ángel ; Recio, Isidra ; Aleixandre, Amaya
KeywordsAngiotensin converting enzyme inhibitory activity
Food peptides
Hypertension
Milk proteins
Spontaneously hypertensive rats
Issue DateOct-2010
PublisherWiley-VCH
CitationMolecular Nutrition and Food Research 54(10): 1422-1427 (2010)
AbstractIn this study we evaluated the short-term oral antihypertensive effect of several peptide sequences isolated from casein fractions, previously characterized as in vitro angiotensin-converting enzyme-inhibitors, in spontaneously hypertensive rats (SHR). Systolic blood pressure (SBP) and the diastolic blood pressure (DBP) of the rats were measured by the tail cuff method before administration and also 2, 4, 6, 8 and 24 h post-administration. The sequences LVYPFTGPIPN, HLPLP, IAK, YAKPVA and WQVLPNAVPAK showed a clear decrease in SBP and DBP in SHR. HPHPHLSF caused a significant decrease of the DBP in the SHR, but this sequence did not modify the SBP of these animals in a significant manner. KKYNVPQL did not modify SBP in the SHR, and caused a slight, but significant and maintained, decrease in DBP in these animals. SBP and DBP returned to baseline values 24 h post-administration of all peptides. In conclusion, these peptides are bioactive ingredients with potential benefit in the prevention and treatment of hypertension or other associated disorders.
Description6 páginas, 3 figuras, 1 tabla.
Publisher version (URL)http://dx.doi.org/10.1002/mnfr.200900448
URIhttp://hdl.handle.net/10261/49756
DOI10.1002/mnfr.200900448
ISSN1613-4125
E-ISSN1613-4133
Appears in Collections:(IFI) Artículos
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