Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/49738COMPARTIR / EXPORTAR:
 SHARE
 CORE
BASE
|
|
| Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
| Título: | GITR contributes to the systemic adjuvanticity of the Escherichia coli heat-labile enterotoxin |
Autor: | Iglesias, Marcos CSIC; Santiuste, Inés CSIC; Merino, Ramón CSIC ORCID; Merino, Jesús | Palabras clave: | Costimulation Costimulation Vaccination |
Fecha de publicación: | mar-2010 | Editor: | Wiley-VCH | Citación: | European Journal of Immunology 40(3): 754-763 (2010) | Resumen: | The Escherichia coli heat-labile enterotoxin (LT) possesses a powerful mucosal and systemic adjuvant effect. However, little is known about the cellular and molecular basis of the immunostimulatory activity of LT at the mucosal level, and even less information is available on the mechanisms underlying its systemic adjuvant activity. In this study, we show that distinct mechanisms are responsible for the parenteral and mucosal adjuvanticity of LT. Indeed, the systemic administration of LT upregulates the expression of glucocorticoid-induced TNFR-related protein (GITR), but not other activation markers, in naive T cells. Using WT and GITR-deficient mice and LT and its enzymatically inactive mutant LTK63 as adjuvants, we show that the induction of GITR expression in T cells accounts for the systemic immunostimulatory capacity of LT, which requires an intact enzymatic activity. In contrast, the mucosal administration of LT does not induce GITR expression on Peyer's patche T cells and accordingly no differences are observed in the mucosal adjuvanticity of LT between WT and GITR-deficient mice. Altogether, our results demonstrate the distinct effect of LT after parenteral administration when compared with the mucosal delivery, and describe a new mechanism of LT adjuvanticity related to its ability to induce the expression of GITR in CD4+ T cells. | Descripción: | El pdf del artículo es el manuscrito de autor.-- et al. | Versión del editor: | http://dx.doi.org/10.1002/eji.200939865 | URI: | http://hdl.handle.net/10261/49738 | DOI: | 10.1002/eji.200939865 | ISSN: | 0014-2980 |
| Aparece en las colecciones: | (IBBTEC) Artículos |
Ficheros en este ítem:
| Fichero | Descripción | Tamaño | Formato | |
|---|---|---|---|---|
| GITR contributes to the systemic adjuvanticity of.pdf | 344,99 kB | Adobe PDF |  Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
2
checked on 31-mar-2024
WEB OF SCIENCETM
Citations
2
checked on 24-feb-2024
Page view(s)
294
checked on 19-abr-2024
Download(s)
292
checked on 19-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.