Please use this identifier to cite or link to this item:
http://hdl.handle.net/10261/49715
Share/Export:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Title: | Interference with p53 functions in human viral infections, a target for novel antiviral strategies? |
Authors: | Lazo, Pedro A. CSIC ORCID ; Santos, Claudio R. | Keywords: | p53 Viral infection |
Issue Date: | 2011 | Publisher: | John Wiley & Sons | Citation: | Reviews in Medical Virology 21(5): 285-300 (2011) | Abstract: | Viral infections cause a major stress in host cells. The cellular responses to stress are mediated by p53, which by deregulation of cell cycle and apoptosis, may also be part of the host cell reaction to fight infections. Therefore, during evolutionary viral adaptation to host organisms, viruses have developed strategies to manipulate host cell p53 dependent pathways to facilitate their viral life cycles. Thus, interference with p53 function is an important component in viral pathogenesis. Many viruses have proteins that directly affect p53, while others alter the regulation of p53 in an indirect manner, mediated by hdm2 or akt, or induction of interferon. Rescue of p53 activity is becoming an area of therapeutic development in oncology. It might be feasible that manipulation of p53 mediated responses can become a therapeutic option to limit viral replication or dissemination. In this report, the mechanisms by which viral proteins manipulate p53 responses are reviewed, and it is proposed that a pharmacological rescue of p53 functions might help to control viral infections. | Publisher version (URL): | http://dx.doi.org/10.1002/rmv.696 | URI: | http://hdl.handle.net/10261/49715 | DOI: | 10.1002/rmv.696 | ISSN: | 1052-9276 |
Appears in Collections: | (IBMCC) Artículos |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
RMV revised virus-p53.pdf | 155,48 kB | Adobe PDF | View/Open |
CORE Recommender
SCOPUSTM
Citations
29
checked on Apr 20, 2024
WEB OF SCIENCETM
Citations
27
checked on Feb 21, 2024
Page view(s)
294
checked on Apr 23, 2024
Download(s)
668
checked on Apr 23, 2024
Google ScholarTM
Check
Altmetric
Altmetric
WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.