Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/49715
Título : Interference with p53 functions in human viral infections, a target for novel antiviral strategies?
Autor : Lazo, Pedro A., Santos, Claudio R.
Palabras clave : p53
Viral infection
Fecha de publicación : 2011
Editor: John Wiley & Sons
Citación : Reviews in Medical Virology 21(5): 285-300 (2011)
Resumen: Viral infections cause a major stress in host cells. The cellular responses to stress are mediated by p53, which by deregulation of cell cycle and apoptosis, may also be part of the host cell reaction to fight infections. Therefore, during evolutionary viral adaptation to host organisms, viruses have developed strategies to manipulate host cell p53 dependent pathways to facilitate their viral life cycles. Thus, interference with p53 function is an important component in viral pathogenesis. Many viruses have proteins that directly affect p53, while others alter the regulation of p53 in an indirect manner, mediated by hdm2 or akt, or induction of interferon. Rescue of p53 activity is becoming an area of therapeutic development in oncology. It might be feasible that manipulation of p53 mediated responses can become a therapeutic option to limit viral replication or dissemination. In this report, the mechanisms by which viral proteins manipulate p53 responses are reviewed, and it is proposed that a pharmacological rescue of p53 functions might help to control viral infections.
Versión del editor: http://dx.doi.org/10.1002/rmv.696
URI : http://hdl.handle.net/10261/49715
ISSN: 1052-9276
Citación : Reviews in Medical Virology 21(5): 285-300 (2011)
Appears in Collections:(IBMCC) Artículos

Files in This Item:
File Description SizeFormat 
RMV revised virus-p53.pdf155,48 kBAdobe PDFView/Open
Show full item record
 
CSIC SFX LinksSFX Query

Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.