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http://hdl.handle.net/10261/49632
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dc.contributor.author | Hernández, Agustín | - |
dc.contributor.author | López-Lluch, Guillermo | - |
dc.contributor.author | Pérez-Castiñeira, J. R. | - |
dc.contributor.author | Serrano-Bueno, Gloria | - |
dc.contributor.author | Navas, Plácido | - |
dc.contributor.author | Serrano, Aurelio | - |
dc.date.accessioned | 2012-05-14T10:19:42Z | - |
dc.date.available | 2012-05-14T10:19:42Z | - |
dc.date.issued | 2011-12-12 | - |
dc.identifier.citation | XIV Congresos de la Sociedad Española de Biología Celular (2011) | es_ES |
dc.identifier.uri | http://hdl.handle.net/10261/49632 | - |
dc.description | Resumen del póster presentado al XIV Congresos de la Sociedad Española de Biología Celular, celebrado en Málaga del 12 al 15 de diciembre de 2011. | es_ES |
dc.description.abstract | Toxic sterol precursors, such as 8-dehydrosterols, are present in a wide range of biologically relevant situations, from human rare diseases such as Conradi-Hünnermann-Happle Syndrome to amine fungicide-treated fungi and crops. However, the molecular and cellular bases of their toxicity are still obscure. Here we show that 8-dehydrosterols affect vacuole acidification producing Vma--like phenotypes in Saccharomyces cerevisiae. Upon expression of a gene construct of the proton-pumping membrane-embedded pyrophosphatase AVP1 from the plant Arabidopsis thaliana as an alternative proton pump, erg2 -derived strains revert their Vma--like phenotypes and wild-type cells can proliferate in the presence of lethal concentrations of tridemorph. Also, endo- and exocytotic defects in erg2 mutants are alleviated by the presence of a plant H+-pyrophosphatase. Despite their effect on endo/exocytic traffic, 8-dehydrosterols do not induce endoplasmic reticulum stress or assembly defects on the V-ATPase. On the contrary, they exert their influence directly at the vacuole level by inducing PEP4-dependent proteolytic degradation of V0 components, like a subunit Vph1p. These results can help to understand the etiology of sterol-related diseases, the fungicidal effect of amine compounds and the tolerance to this type of compounds observed in certain field fungi isolates and, in general, in plants. | - |
dc.description.sponsorship | Supported by grant P07-CVI-3082 and group CVI-261 from Andalusian Administration and grant BFU2010-15622 (FEDER). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Sociedad Española de Biología Celular | es_ES |
dc.rights | closedAccess | es_ES |
dc.subject | Toxic sterol precursors | es_ES |
dc.subject | 8-dehydrosterols | es_ES |
dc.subject | Conradi-Hünnermann-Happle syndrome | es_ES |
dc.subject | Saccharomyces cerevisiae proteins | es_ES |
dc.title | 8-Dehydrosterols induce v-atpase dysfunction in yeast. Protective effect of an alternative H+-PUMP | es_ES |
dc.type | póster de congreso | es_ES |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.contributor.funder | Junta de Andalucía | - |
dc.contributor.funder | Ministerio de Ciencia e Innovación (España) | - |
dc.relation.csic | Sí | - |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004837 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100011011 | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6670 | es_ES |
item.openairetype | póster de congreso | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
item.languageiso639-1 | en | - |
Aparece en las colecciones: | (IBVF) Comunicaciones congresos (CABD) Comunicaciones congresos |
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