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Open Access item Resveratrol-induce s-phase delay in cell cycle depends on cell metabolism

Authors:Santa-Cruz Calvo, Sara
Navas, Plácido
López-Lluch, Guillermo
Keywords:Polyphenols, Cell cycle, Resveratrol (RSV), Tumor, Protein
Issue Date:12-Dec-2011
Publisher:Sociedad Española de Biología Celular
Citation:Libro de resúmenes : 146 (2011)
Abstract:The effect of polyphenols in cell cycle progression of tumor cell lines is widely known. Among polyphenols, resveratrol (RSV) is a stilbenoid known to activate sirtuins and to show prolongevity effects (Baur et al., 2006). Treatment of tumor cell lines with RSV produces a dose-dependent S-phase delay starting as early as 6-12 hours of incubation. Cell cycle distribution seems to return to normal values with time and depends on the dose of RSV. This delay occurs in both cell lines expressing and lacking p53. However, in cell lines able to express p53, RSV increases its protein levels and also the levels of downstream targets such as p21.
Description:1 página.
Publisher version (URL):http://www.congresosebc2011.uma.es/documentos/LibroAbstractsSEBC2011.pdf
URI:http://hdl.handle.net/10261/49627
Appears in Collections:(CABD) Comunicaciones congresos

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