Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/49627
Title: Resveratrol-induce s-phase delay in cell cycle depends on cell metabolism
Authors: Santa-Cruz Calvo, Sara, Navas, Plácido, López-Lluch, Guillermo
Keywords: Polyphenols
Cell cycle
Resveratrol (RSV)
Tumor
Protein
Issue Date: 12-Dec-2011
Publisher: Sociedad Española de Biología Celular
Abstract: The effect of polyphenols in cell cycle progression of tumor cell lines is widely known. Among polyphenols, resveratrol (RSV) is a stilbenoid known to activate sirtuins and to show prolongevity effects (Baur et al., 2006). Treatment of tumor cell lines with RSV produces a dose-dependent S-phase delay starting as early as 6-12 hours of incubation. Cell cycle distribution seems to return to normal values with time and depends on the dose of RSV. This delay occurs in both cell lines expressing and lacking p53. However, in cell lines able to express p53, RSV increases its protein levels and also the levels of downstream targets such as p21.
Description: 1 página.
Publisher version (URL): http://www.congresosebc2011.uma.es/documentos/LibroAbstractsSEBC2011.pdf
URI: http://hdl.handle.net/10261/49627
Citation: Libro de resúmenes : 146 (2011)
Appears in Collections:(CABD) Comunicaciones congresos

Files in This Item:
File Description SizeFormat 
AbstractsSEBC2011_CABD3.pdf56,29 kBAdobe PDFView/Open
Show full item record
 
CSIC SFX LinksSFX Query

Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.