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Título: | TGF-β/TGF-β receptor system and its role in physiological and pathological conditions |
Autor: | Santibáñez, Juan F. CSIC ORCID; Quintanilla, Miguel CSIC ORCID; Bernabéu, Carmelo CSIC ORCID | Palabras clave: | Cancer Cardiovascular disease Fibrosis TGF-β |
Fecha de publicación: | 2011 | Editor: | Portland Press Biochemical Society |
Citación: | Clinical Science 121(6): 233-251(2011) | Resumen: | The TGF-β (transforming growth factor-β) system signals via protein kinase receptors and Smad mediators to regulate a plethora of biological processes, including morphogenesis, embryonic development, adult stem cell differentiation, immune regulation, wound healing and inflammation. In addition, alterations of specific components of the TGF-β signalling pathway may contribute to a broad range of pathologies such as cancer, cardiovascular pathology, fibrosis and congenital diseases. The knowledge about the mechanisms involved in TGF-β signal transduction has allowed a better understanding of the disease pathogenicity as well as the identification of several molecular targets with great potential in therapeutic interventions. | Descripción: | 36 p.-3 fig.-3 tab. | Versión del editor: | http://dx.doi.org/10.1042/CS20110086 | URI: | http://hdl.handle.net/10261/49444 | DOI: | 10.1042/CS20110086 | ISSN: | 0143-5221 | E-ISSN: | 1470-8736 |
Aparece en las colecciones: | (CIB) Artículos (IIBM) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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TGFß RECEPTOR.pdf | 649,85 kB | Adobe PDF | Visualizar/Abrir |
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