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http://hdl.handle.net/10261/49398
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Casar, Berta | - |
dc.contributor.author | Sanz-Moreno, Victoria | - |
dc.contributor.author | Yazicioglu, Mustafa N. | - |
dc.contributor.author | Rodríguez, Javier | - |
dc.contributor.author | Berciano, María T. | - |
dc.contributor.author | Lafarga, Miguel | - |
dc.contributor.author | Cobb, Melanie H. | - |
dc.contributor.author | Crespo, Piero | - |
dc.date.accessioned | 2012-05-08T13:20:35Z | - |
dc.date.available | 2012-05-08T13:20:35Z | - |
dc.date.issued | 2007 | - |
dc.identifier.citation | EMBO Journal 26(3): 635-646 (2007) | es_ES |
dc.identifier.issn | 0261-4189 | - |
dc.identifier.uri | http://hdl.handle.net/10261/49398 | - |
dc.description.abstract | Spatial regulation of ERK1/2 MAP kinases is an essential yet largely unveiled mechanism for ensuring the fidelity and specificity of their signals. Mxi2 is a p38 isoform with the ability to bind ERK1/2. Herein we show that Mxi2 has profound effects on ERK1/2 nucleocytoplasmic distribution, promoting their accumulation in the nucleus. Downregulation of endogenous Mxi2 by RNAi causes a marked reduction of ERK1/2 in the nucleus, accompanied by a pronounced decline in cellular proliferation. We demonstrate that Mxi2 functions in nuclear shuttling of ERK1/2 by enhancing the nuclear accumulation of both phosphorylated and unphosphorylated forms in the absence of stimulation. This process requires the direct interaction of both proteins and a high-affinity binding of Mxi2 to ERK-binding sites in nucleoporins, In this respect, Mxi2 acts antagonistically to PEA15, displacing it from ERK1/2 complexes. These results point to Mxi2 as a key spatial regulator for ERK1/2 and disclose an unprecedented stimulus-independent mechanism for ERK nuclear import. | es_ES |
dc.description.sponsorship | PC lab is supported by grants BMC2002-01021 and GEN2003-20239-C06-03 from the Spanish Ministry of Education. MHC lab is supported by NIH grant DK34128. ML and MTB are supported by grant BFI2002-00454 from the Spanish Ministry of Education. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Nature Publishing Group | es_ES |
dc.publisher | John Wiley & Sons | - |
dc.rights | closedAccess | es_ES |
dc.subject | ERK | es_ES |
dc.subject | MAP kinases | es_ES |
dc.subject | Mxi2 | es_ES |
dc.subject | Nuclear import | es_ES |
dc.title | Mxi2 promotes stimulus-independent ERK nuclear translocation | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1038/sj.emboj.7601523 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.1038/sj.emboj.7601523 | es_ES |
dc.identifier.pmid | 17255949 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
item.cerifentitytype | Publications | - |
item.openairetype | artículo | - |
item.languageiso639-1 | en | - |
item.grantfulltext | none | - |
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