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Title

Altered arachidonate distribution in macrophages from caveolin-1 null mice leading to a reduced eicosanoid synthesis

AuthorsAstudillo, Alma M. ; Pérez-Chacón, Gema ; Meana, Clara ; Balgoma, David ; Pol, Albert; Pozo, Miguel A. del; Balboa, María A. ; Balsinde, Jesús
Issue DateOct-2011
PublisherAmerican Society for Biochemistry and Molecular Biology
CitationJournal of Biological Chemistry 286(40): 35299-35307 (2011)
AbstractIn this work we have studied the effect of caveolin-1 deficiency on the mechanisms that regulate free arachidonic acid (AA) availability. Results presented here demonstrate that macrophages from caveolin-1-deficient mice exhibit elevated fatty acid incorporation and remodeling and a constitutively increased CoA-independent transacylase activity. Mass spectrometry-based lipidomic analyses reveal stable alterations in the profile of AA distribution among phospholipids, manifested by reduced levels of AA in choline glycerophospholipids but elevated levels in ethanolamine glycerophospholipids and phosphatidylinositol. Furthermore, macrophages from caveolin-1 null mice show decreased AA mobilization and PGE 2 and LTB4 production upon cell stimulation. Collectively, these results provide insight into the role of caveolin-1 in AA homeostasis and suggest an important role for this protein in the eicosanoid biosynthetic response.
Description20 páginas, 7 figuras, 1 tabla.-- El pdf del artículo es la versión post-print.
Publisher version (URL)http://dx.doi.org/10.1074/jbc.M111.277137
URIhttp://hdl.handle.net/10261/49272
DOI10.1074/jbc.M111.277137
ISSN0021-9258
E-ISSN1083-351X
Appears in Collections:(IBGM) Artículos
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