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Deciphering the physiological blueprint of a bacterial cell: Revelations of unanticipated complexity in transcriptome and proteome

AuthorsToledo-Arana, Alejandro ; Solano Goñi, Cristina
KeywordsGenome-wide transcriptomics
Issue DateJun-2010
PublisherJohn Wiley & Sons
CitationBioEssays 32(6): 461-467 (2010)
AbstractDuring the last few months, several pioneer genome-wide transcriptomic, proteomic and metabolomic studies have revolutionised the understanding of bacterial biological processes, leading to a picture that resembles eukaryotic complexity. Technological advances such as next-generation high-throughput sequencing and high-density oligonucleotide microarrays have allowed the determination, in several bacteria, of the entire boundaries of all expressed transcripts. Consequently, novel RNA-mediated regulatory mechanisms have been discovered including multifunctional RNAs. Moreover, resolution of bacterial proteome organisation (interactome) and global protein localisation (localizome) have unveiled an unanticipated complexity that highlights the significance of protein multifunctionality and localisation in the cell. Also, analysis of a complete bacterial metabolic network has again revealed a high fraction of multifunctional enzymes and an unexpectedly high level of metabolic responses and adaptation. Altogether, these novel approaches have permitted the deciphering of the entire physiological landscape of one of the smallest bacteria, Mycoplasma pneumoniae. Here, we summarise and discuss recent findings aimed at defining the blueprint of any prokaryote.
Description7 p., 3 figures and bibliography
Publisher version (URL)http://dx.doi.org/10.1002/bies.201000020
Appears in Collections:(IDAB) Artículos
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