English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/48424
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Title

Invasive Cell Behavior during Drosophila Imaginal Disc Eversion Is Mediated by the JNK Signaling Cascade

AuthorsPastor-Pareja, José Carlos; Grawe, Ferdinand; Martín-Blanco, Enrique ; García-Bellido, Antonio
KeywordsDrosophila
Larvae
Imaginal
Disc
Exoskeleton
PEMT
Issue DateSep-2004
PublisherCell Press
CitationDevelopmental Cell 7 (3): 387–399 (2204)
AbstractDrosophila imaginal discs are monolayered epithelial invaginations that grow during larval stages and evert at metamorphosis to assemble the adult exoskeleton. They consist of columnar cells, forming the imaginal epithelium, as well as squamous cells, which constitute the peripodial epithelium and stalk (PS). Here, we uncover a new morphogenetic/cellular mechanism for disc eversion. We show that imaginal discs evert by apposing their peripodial side to the larval epidermis and through the invasion of the larval epidermis by PS cells, which undergo a pseudo-epithelial-mesenchymal transition (PEMT). As a consequence, the PS/larval bilayer is perforated and the imaginal epithelia protrude, a process reminiscent of other developmental events, such as epithelial perforation in chordates. When eversion is completed, PS cells localize to the leading front, heading disc expansion. We found that the JNK pathway is necessary for PS/larval cells apposition, the PEMT, and the motile activity of leading front cells.
Publisher version (URL)http://dx.doi.org/10.1016/j.devcel.2004.07.022
URIhttp://hdl.handle.net/10261/48424
DOI10.1016/j.devcel.2004.07.022
ISSN1534-5807
Appears in Collections:(CBM) Artículos
Files in This Item:
File Description SizeFormat 
Embargo.pdf21,67 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.