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dc.contributor.author | Palacios-Rodríguez, Yadira | - |
dc.contributor.author | García-Laínez, Guillermo | - |
dc.contributor.author | Sancho, Mónica | - |
dc.contributor.author | Gortat, Anna | - |
dc.contributor.author | Orzáez, Mar | - |
dc.contributor.author | Pérez-Payá, Enrique | - |
dc.date.accessioned | 2012-04-11T10:11:39Z | - |
dc.date.available | 2012-04-11T10:11:39Z | - |
dc.date.issued | 2011-11-07 | - |
dc.identifier.citation | Journal of Biological Chemistry 286(52):44457-66 (2011 Dec 30) | es_ES |
dc.identifier.issn | 0021-9258 | - |
dc.identifier.uri | http://hdl.handle.net/10261/48108 | - |
dc.description | 10 páginas, 7 figuras, 3 tablas. PMID:22065589[PubMed] PMCID:PMC3247988[Available on 2012/12/30] | es_ES |
dc.description.abstract | The caspase recruitment domain (CARD) is present in a large number of proteins. Initially, the CARD was recognized as part of the caspase activation machinery. CARD-CARD interactions play a role in apoptosis and are responsible for the Apaf-1-mediated activation of procaspase-9 in the apoptosome. CARD-containing proteins mediate the inflammasome-dependent activation of proinflammatory caspase-1. More recently, new roles for CARD-containing proteins have been reported in signaling pathways associated with immune responses. The functional role of CARD-containing proteins and CARDs in coordinating apoptosis and inflammatory and immune responses is not completely understood. We have explored the putative cross-talk between apoptosis and inflammation by analyzing the modulatory activity on both the Apaf-1/procaspase-9 interaction and the inflammasome-mediated procaspase-1 activation of CARD-derived polypeptides. To this end, we analyzed the activity of individual recombinant CARDs, rationally designed CARD-derived peptides, and peptides derived from phage display. | es_ES |
dc.description.sponsorship | This work has been supported by grants from the Spanish Ministry of Science and Innovation (MICINN - BIO2007-60066 and SAF2010 15512), Laboratorios Salvat, SA, Generalitat Valenciana Prometeo 2010/005 (partially funded with ERDF) and Consolider-Ingenio 2010 (MICINN - CSD2008-00005C) to E.P.-P. Y. P.-R. was supported by a postdoctoral fellowship from the National Autonomous University of Mexico and Consejo Superior de Investigaciones Científicas, Spain (UNAM - CSIC). G. G.-L. acknowledges financial support through JAE-Pre from the CSIC. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | American Society for Biochemistry and Molecular Biology | es_ES |
dc.rights | openAccess | es_ES |
dc.subject | Apaf-1 | es_ES |
dc.subject | Apoptosis | es_ES |
dc.subject | Apoptosome | es_ES |
dc.subject | Caspase-1 | es_ES |
dc.subject | Caspase-9 | es_ES |
dc.subject | CarD | es_ES |
dc.subject | Inflammasome | es_ES |
dc.subject | Inhibitors | es_ES |
dc.subject | NLRP-1 | es_ES |
dc.subject | NOD | es_ES |
dc.subject | ASC | es_ES |
dc.subject | peptides | es_ES |
dc.subject | procaspase-1 | es_ES |
dc.subject | procaspase-9 | es_ES |
dc.subject | protein-protein | es_ES |
dc.title | Polypeptide modulators of caspase recruitment domain (CARD)-CARD-mediated protein-protein interactions | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1074/jbc.M111.255364 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.1074/jbc.M111.255364 | es_ES |
dc.identifier.e-issn | 1083-351X | - |
dc.embargo.terms | 2012-12-30 | es_ES |
dc.identifier.pmid | 22065589 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
item.languageiso639-1 | en | - |
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