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Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/48108
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Title: Polypeptide modulators of caspase recruitment domain (CARD)-CARD-mediated protein-protein interactions
Authors: Palacios-Rodríguez, Yadira; García-Laínez, Guillermo; Sancho, Mónica; Gortat, Anna; Orzáez, Mar; Pérez-Payá, Enrique
Keywords: Apaf-1
apoptosis
apoptosome
caspase-1
caspase-9
CARD
inflammasome
inhibitors
NLRP-1
NOD
ASC
peptides
procaspase-1
procaspase-9
protein-protein
Issue Date: 7-Nov-2011
Publisher: American Society for Biochemistry and Molecular Biology
Citation: Journal of Biological Chemistry 286(52):44457-66 (2011 Dec 30)
Abstract: The caspase recruitment domain (CARD) is present in a large number of proteins. Initially, the CARD was recognized as part of the caspase activation machinery. CARD-CARD interactions play a role in apoptosis and are responsible for the Apaf-1-mediated activation of procaspase-9 in the apoptosome. CARD-containing proteins mediate the inflammasome-dependent activation of proinflammatory caspase-1. More recently, new roles for CARD-containing proteins have been reported in signaling pathways associated with immune responses. The functional role of CARD-containing proteins and CARDs in coordinating apoptosis and inflammatory and immune responses is not completely understood. We have explored the putative cross-talk between apoptosis and inflammation by analyzing the modulatory activity on both the Apaf-1/procaspase-9 interaction and the inflammasome-mediated procaspase-1 activation of CARD-derived polypeptides. To this end, we analyzed the activity of individual recombinant CARDs, rationally designed CARD-derived peptides, and peptides derived from phage display.
Description: 10 páginas, 7 figuras, 3 tablas. PMID:22065589[PubMed] PMCID:PMC3247988[Available on 2012/12/30]
Publisher version (URL): http://dx.doi.org/10.1074/jbc.M111.255364
URI: http://hdl.handle.net/10261/48108
ISSN: 0021-9258
DOI: 10.1074/jbc.M111.255364
E-ISSN: 1083-351X
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